PDB entry 6xqp

View 6xqp on RCSB PDB site
Description: Structure of human D462-E4 TCR in complex with human MR1-5-OP-RU
Class: immune system
Keywords: MAIT, MR1, Metabolite presentation, IMMUNE SYSTEM
Deposited on 2020-07-10, released 2020-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • conflict (261)
    Domains in SCOPe 2.08: d6xqpa1
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6xqpb1, d6xqpb2
  • Chain 'C':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-270)
      • conflict (261)
    Domains in SCOPe 2.08: d6xqpc1, d6xqpc2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d6xqpd1, d6xqpd2
  • Chain 'E':
    Compound: TRAV12-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XQP
    Domains in SCOPe 2.08: d6xqpe1, d6xqpe2
  • Chain 'F':
    Compound: trbv29-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XQP
    Domains in SCOPe 2.08: d6xqpf1, d6xqpf2
  • Chain 'G':
    Compound: TRAV12-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XQP
    Domains in SCOPe 2.08: d6xqpg1, d6xqpg2
  • Chain 'H':
    Compound: trbv29-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XQP
    Domains in SCOPe 2.08: d6xqph1, d6xqph2
  • Heterogens: 2LJ, GOL, BR, NA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xqpA (A:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpA (A:)
rthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhwe
rytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdfl
ifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrte
pplvrvnrketlfckahgfyppeiymtweidygdilpsgdgtyqawasichvehsgvhmv
lqv

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6xqpB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xqpC (C:)
mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
awasieldpqssnlyschvehsgvhmvlqvp

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpC (C:)
rthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhwe
rytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdfl
ifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrte
pplvrvnrtalfckahgfyppeiymtwmkngeeidygdilpsgdgtyqawasiesnlysc
hvehsgvhmvlqvp

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6xqpD (D:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6xqpE (E:)
mqkeveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedg
rftaqlnkasqyvsllirdsqpsdsatylcavrdagnmltfgggtrlmvkpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpE (E:)
eveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgrft
aqlnkasqyvsllirdsqpsdsatylcavrdagnmltfgggtrlmvkpniqnpdpavyql
rdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfacanaf
nnsiipedtffps

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6xqpF (F:)
msavisqkpsrdicqrgtsltiqcqvdsqvtmmfwyrqqpgqsltliatanqgseatyes
gfvidkfpisrpnltfstltvsnmspedssiylcsvggdslignqpqhfgdgtrlsiled
lknvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqp
lkeqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivs
aeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpF (F:)
savisqkpsrdicqrgtsltiqcqvdsqvtmmfwyrqqpgqsltliatanqgseatyesg
fvidkfpisrpnltfstltvsnmspedssiylcsvggdslignqpqhfgdgtrlsiledl
knvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqpl
keqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsa
eawgra

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6xqpG (G:)
mqkeveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedg
rftaqlnkasqyvsllirdsqpsdsatylcavrdagnmltfgggtrlmvkpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpG (G:)
eveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgrft
aqlnkasqyvsllirdsqpsdsatylcavrdagnmltfgggtrlmvkpniqnpdpavyql
rdsksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfacana
fnnsiipedtffps

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6xqpH (H:)
msavisqkpsrdicqrgtsltiqcqvdsqvtmmfwyrqqpgqsltliatanqgseatyes
gfvidkfpisrpnltfstltvsnmspedssiylcsvggdslignqpqhfgdgtrlsiled
lknvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqp
lkeqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivs
aeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >6xqpH (H:)
savisqkpsrdicqrgtsltiqcqvdsqvtmmfwyrqqpgqsltliatanqgseatyesg
fvidkfpisrpnltfstltvsnmspedssiylcsvggdslignqpqhfgdgtrlsiledl
knvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqpl
keqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsa
eawgra