PDB entry 6xpp

View 6xpp on RCSB PDB site
Description: Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase
Class: lyase
Keywords: covalent modification, LYASE
Deposited on 2020-07-08, released 2020-10-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icl, Rv0467, MTV038.11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xppa_
  • Chain 'B':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icl, Rv0467, MTV038.11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xppb_
  • Chain 'C':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icl, Rv0467, MTV038.11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xppc_
  • Chain 'D':
    Compound: isocitrate lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: icl, Rv0467, MTV038.11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xppd_
  • Heterogens: ITN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xppA (A:)
msvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xppA (A:)
svvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweqlh
dlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqvv
rrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagshw
edqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsdv
derdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfseav
kaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfdl
aygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltgs
teegqf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xppB (B:)
msvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xppB (B:)
svvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweqlh
dlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqvv
rrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagshw
edqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsdv
derdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfseav
kaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfdl
aygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltgs
teeg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xppC (C:)
msvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xppC (C:)
svvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweqlh
dlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqvv
rrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagshw
edqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsdv
derdqpfitrtregfyrtkngiepciarakayapfadliwmetgtpdleaarqfseavka
eypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfdlay
gyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltgste
egqfh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xppD (D:)
msvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqfh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xppD (D:)
msvvgtpksaeqiqqewdtnprwkdvtrtysaedvvalqgsvveehtlarrgaevlweql
hdlewvnalgaltgnmavqqvraglkaiylsgwqvagdanlsghtypdqslypansvpqv
vrrinnalqradqiakiegdtsvenwlapivadgeagfggalnvyelqkaliaagvagsh
wedqlasekkcghlggkvliptqqhirtltsarlaadvadvptvviartdaeaatlitsd
vderdqpfitgertregfyrtkngiepciarakayapfadliwmetgtpdleaarqfsea
vkaeypdqmlayncspsfnwkkhlddatiakfqkelaamgfkfqfitlagfhalnysmfd
laygyaqnqmsayvelqerefaaeergytatkhqrevgagyfdriattvdpnssttaltg
steegqf