PDB entry 6xp6

View 6xp6 on RCSB PDB site
Description: 3C11-DQ2-glia-a2 complex
Class: peptide binding protein
Keywords: Complex Antibody Human Leucocyte Antigen, PEPTIDE BINDING PROTEIN
Deposited on 2020-07-08, released 2021-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class II HLA-DQ-alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O19705 (0-182)
      • expression tag (183-190)
    Domains in SCOPe 2.08: d6xp6a1, d6xp6a2
  • Chain 'B':
    Compound: MHC class II HLA-DQ-beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O19712 (1-192)
      • expression tag (0)
      • expression tag (193-200)
    Domains in SCOPe 2.08: d6xp6b1, d6xp6b2
  • Chain 'C':
    Compound: DQ2-glia-a2 peptide
    Species: Triticum aestivum [TaxId:4565]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-25)
  • Chain 'D':
    Compound: MHC class II HLA-DQ-alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O19705 (0-182)
      • expression tag (183-190)
    Domains in SCOPe 2.08: d6xp6d1, d6xp6d2
  • Chain 'E':
    Compound: MHC class II HLA-DQ-beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DQB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O19712 (1-192)
      • expression tag (0)
      • expression tag (193-200)
    Domains in SCOPe 2.08: d6xp6e1, d6xp6e2
  • Chain 'F':
    Compound: DQ2-glia-a2 peptide
    Species: Triticum aestivum [TaxId:4565]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-25)
  • Chain 'G':
    Compound: 3.C11 IgK Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-213)
    Domains in SCOPe 2.08: d6xp6g_
  • Chain 'H':
    Compound: 3.C11 IgH Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-223)
    Domains in SCOPe 2.08: d6xp6h_
  • Chain 'I':
    Compound: 3.C11 IgK Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-213)
    Domains in SCOPe 2.08: d6xp6i_
  • Chain 'J':
    Compound: 3.C11 IgH Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP6 (0-223)
    Domains in SCOPe 2.08: d6xp6j_
  • Heterogens: NAG, IPA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xp6A (A:)
edivadhvasygvnlyqsygpsgqythefdgdeqfyvdlgrketvwclpvlrqfrfdpqf
altniavlkhnlnslikrsnstaatnevpevtvfskspvtlgqpniliclvdnifppvvn
itwlsnghsvtegvsetsflsksdhsffkisyltllpsaeesydckvehwgldkpllkhw
epetsgddddk

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6A (A:)
ivadhvasygvnlyqsygpsgqythefdgdeqfyvdlgrketvwclpvlrqfrfdpqfal
tniavlkhnlnslikrsnstaatnevpevtvfskspvtlgqpniliclvdnifppvvnit
wlsnghsvtegvsetsflsksdhsffkisyltllpsaeesydckvehwgldkpllkhwep
e

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xp6B (B:)
srdspedfvyqfkgmcyftngtervrlvsrsiynreeivrfdsdvgefravtllglpaae
ywnsqkdilerkraavdrvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsv
tdfypaqikvrwfrndqeetagvvstplirngdwtfqilvmlemtpqrgdvytchvehps
lqspitvewraqstggddddk

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6B (B:)
dspedfvyqfkgmcyftngtervrlvsrsiynreeivrfdsdvgefravtllglpaaeyw
nsqkdilerkraavdrvcrhnyqlelrttlqrrveptvtispsnllvcsvtdfypaqikv
rwfrndqeetagvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqspitvewr
a

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xp6D (D:)
edivadhvasygvnlyqsygpsgqythefdgdeqfyvdlgrketvwclpvlrqfrfdpqf
altniavlkhnlnslikrsnstaatnevpevtvfskspvtlgqpniliclvdnifppvvn
itwlsnghsvtegvsetsflsksdhsffkisyltllpsaeesydckvehwgldkpllkhw
epetsgddddk

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6D (D:)
divadhvasygvnlyqsygpsgqythefdgdeqfyvdlgrketvwclpvlrqfrfdpqfa
ltniavlkhnlnslikrsnstaatnevpevtvfskspvtlgqpniliclvdnifppvvni
twlsnghsvtegvsetsflsksdhsffkisyltllpsaeesydckvehwgldkpllkhwe
pe

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6xp6E (E:)
srdspedfvyqfkgmcyftngtervrlvsrsiynreeivrfdsdvgefravtllglpaae
ywnsqkdilerkraavdrvcrhnyqlelrttlqrrveptvtispsrtealnhhnllvcsv
tdfypaqikvrwfrndqeetagvvstplirngdwtfqilvmlemtpqrgdvytchvehps
lqspitvewraqstggddddk

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6E (E:)
spedfvyqfkgmcyftngtervrlvsrsiynreeivrfdsdvgefravtllglpaaeywn
sqkdilerkraavdrvcrhnyqlelrttlqrrveptvtispsnllvcsvtdfypaqikvr
wfrndqeetagvvstplirngdwtfqilvmlemtpqrgdvytchvehpslqspitvewra

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6xp6G (G:)
diqmtqspssvstsvgdrvtitcrasqdisnwlawyqqkpgkapklliydsstlqsgvps
rfsgsgsgtdftltistlqpedfatyycqqfnsypltfgggtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6G (G:)
diqmtqspssvstsvgdrvtitcrasqdisnwlawyqqkpgkapklliydsstlqsgvps
rfsgsgsgtdftltistlqpedfatyycqqfnsypltfgggtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6xp6H (H:)
qvqlvqsgaevkkpgssvkvsckasggtvrsrvhaiswvrqapgqglewmggiipifgta
nyaqkfqgrvtitadeststaymelsslrsedtavyycardvqrmgmdvwgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6H (H:)
qvqlvqsgaevkkpgssvkvsckasggtvrsrvhaiswvrqapgqglewmggiipifgta
nyaqkfqgrvtitadeststaymelsslrsedtavyycardvqrmgmdvwgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6xp6I (I:)
diqmtqspssvstsvgdrvtitcrasqdisnwlawyqqkpgkapklliydsstlqsgvps
rfsgsgsgtdftltistlqpedfatyycqqfnsypltfgggtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6I (I:)
diqmtqspssvstsvgdrvtitcrasqdisnwlawyqqkpgkapklliydsstlqsgvps
rfsgsgsgtdftltistlqpedfatyycqqfnsypltfgggtkvdikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6xp6J (J:)
qvqlvqsgaevkkpgssvkvsckasggtvrsrvhaiswvrqapgqglewmggiipifgta
nyaqkfqgrvtitadeststaymelsslrsedtavyycardvqrmgmdvwgqgttvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp6J (J:)
qvqlvqsgaevkkpgssvkvsckasggtvrsrvhaiswvrqapgqglewmggiipifgta
nyaqkfqgrvtitadeststaymelsslrsedtavyycardvqrmgmdvwgqgttvtvss
astkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvep