PDB entry 6xp5

View 6xp5 on RCSB PDB site
Description: head-middle module of mediator
Deposited on 2020-07-08, released 2021-03-03
The last revision was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: EM
Resolution: 4.2 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'D':
    Compound: Mediator of RNA polymerase II transcription subunit 4
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED4, CTHT_0037540
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Mediator of RNA polymerase II transcription subunit 6
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED6, CTHT_0067530
    Database cross-references and differences (RAF-indexed):
    • Uniprot G0SGT8
      • insertion (135)
      • conflict (228)
  • Chain 'G':
    Compound: Mediator of RNA polymerase II transcription subunit 7
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0064270
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Mediator of RNA polymerase II transcription subunit 8
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED8, CTHT_0058900
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Mediator of RNA polymerase II transcription subunit 9
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED9, CTHT_0016410
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Mediator of RNA polymerase II transcription subunit 11
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED11, CTHT_0068270
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Mediator of RNA polymerase II transcription subunit 14
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0057660
    Database cross-references and differences (RAF-indexed):
    • Uniprot G0SCL5
      • insertion (730-732)
  • Chain 'Q':
    Compound: Mediator of RNA polymerase II transcription subunit 17
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED17, CTHT_0014540
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Mediator of RNA polymerase II transcription subunit 18
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: MED18, CTHT_0007510
    Database cross-references and differences (RAF-indexed):
  • Chain 'U':
    Compound: Mediator of RNA polymerase II transcription subunit 21
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0029550
    Database cross-references and differences (RAF-indexed):
  • Chain 'V':
    Compound: Med22
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0021510
    Database cross-references and differences (RAF-indexed):
    • Uniprot G0S3J8
      • insertion (77)
  • Chain 'Z':
    Compound: Mediator of RNA polymerase II transcription subunit 31
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0015060
    Database cross-references and differences (RAF-indexed):
  • Chain 'a':
    Compound: Mediator of RNA polymerase II transcription subunit 1
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0063280
    Database cross-references and differences (RAF-indexed):
    • Uniprot G0SEC7
      • conflict (239)
      • conflict (317)
  • Chain 'b':
    Compound: Unknown peptide
    Species: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [TaxId:759272]
    Gene: CTHT_0063280
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP5 (0-20)
  • Chain 'c':
    Compound: heat
    Species: CHAETOMIUM THERMOPHILUM [TaxId:209285]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XP5 (0-199)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6xp5D (D:)
mdkeldgrferlekalatmidslsknnpstklaqdlvaaeaelleglklleahqnnhari
qqlrqsteqadaqikdiisslwkmrqeltsvqtspipkgakfqfttgelldfarrisrnt
lpppgvtngvnmtpaaarhsqqpssvepedsfrvtsqsqtqtpntsfnvsfngtlvdtpg
pfnnnstpipnagpansqnphtelpehlklatnplhgasffpwpsveqvrsgalgayqll
vdkgidprgydpefeeqrrkdaereaeerakqereeaerrareeaeriarqrelerqrar
esmaaaaeegrrdsvvggpaagkpkqftflggddddddddd

    Sequence, based on observed residues (ATOM records):
    >6xp5D (D:)
eldgrferlekalatmidslsknnpstklaqdlvaaeaelleglklleahqnnhariqql
rqsteqadaqikdiisslwkmrqeltsvqtspifqfttgelldfarrisrntlpppgvtn
gvnmtpaaarhsqq

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6xp5F (F:)
madpssstsampldeiqwhtnpavvggsihdnsvlfyfrespfydktsnnevlyqqglhn
qtmmqfletrerferrlremsglefvvaqepaetapgtgtgvwvinkqtrrkrqgeedei
svhgtyflvgenvymaaptladiismrlasasssisrllpiaasvqswspgtgrvyktps
mtsqtnqanqpssqtqsqptsqpattttttalpppdprwleetlmiheffgdhhldknpi
tgkpgdfhlsstgrkiqtlptaaagnkkpgsglpplpaintkvqqnpmgsgkqvtgketk
spktpssstgpgtggmstgmgkpkkrksskaavtpts

    Sequence, based on observed residues (ATOM records):
    >6xp5F (F:)
ldeiqwhtnpavvggsihdnsvlfyfrespfydktsnnevlyqqglhnqtmmqfletlre
msglefvvaqetgtgvwvinkqtrrkedeisvhgtyflvgenvymaaptladiismrlas
asssisrllpiaasvqswsppdprwleetlmiheff

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6xp5G (G:)
mdsseddgnkvahlwpdppafwkdftpenierynalkqtyaqqhglssdalvripdvpad
linlqpppepvdgkwklygqqealanslqsledagiqrlapasettsdskhfdrgfelkk
laksllvnylelmgimsinpahasekvqdiktivlnfhhilneyrphqareqliqlmqdh
ldakrnetaavravvdkakrlieglasieipkveddngrkaveveraalaerreiaawqe
adalft

    Sequence, based on observed residues (ATOM records):
    >6xp5G (G:)
lwpdppafwkpenierynalkqtrlapasettsdskhfdrgfelkklaksllvnylelmg
imsinpahasekvqdiktivlnfhhilneyiqlmqdhldakrnetaavravvdkakrlie
gl

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6xp5H (H:)
maslnlapeelkqlellrnrfaqlqssltslagnlirteplptyeslqasasilqqnlrs
iqelmtensdifkriaihpstnfpgrtqehmllqllrkklepeveswveearetaraagi
dvsklsgpgggaptrgmngygdddeyglddedegvpsdpfneqwadmletfqhslhhyvt
vqlkkqytveeqemgienvrtglkrelgdededededeeeeeegvagvaggaasqgagag
tagaaakkpviqpeylfwlaargdtrvsrniefeamrkvaqtakrpappr

    Sequence, based on observed residues (ATOM records):
    >6xp5H (H:)
apeelkqlellrnrfaqlqssltslagnlirteplptyeslqasasilqqnlrsiqelmt
ensdifkriaihpstnfpgrtqehmllqllrkklepeveswveearetarafneqwadml
etfqhslhhyvtvqlkkqytveeqem

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6xp5I (I:)
mtaplpegltpdavdtltelsaiikklraaqqqqaanpssqaaaggpgttgapgsqpsss
gpnataaggaigttslpssattgptpsnalhsvkelpattdpikhklqraraavrllgdm
srtmaqqeaelarleerrrkqaamlakaqeegarlskgfgevgetpvvlvetgdkmame

    Sequence, based on observed residues (ATOM records):
    >6xp5I (I:)
aiikklraaqqqqaanpssqaaaggpgttgapgsqpsssgpnataaggaigttslpssat
tgptpsnalhsvkelpattdpikhklqraraavrll

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6xp5K (K:)
maqpsqssvpesdagsfpvdihkpftpaeriqqlgeidndiasllqhlsaalkalatppg
krifqeqdsesnspsasdtsnpndtppsscgidpvtafktaqndffrtidridkhltrqi
yaleeagiitlksgtgsgagtvgagateeqaqqlpqpqmipgqpqaagitadasvapvpk
arlepdgmgrygkldvgrlnmassiveremegelwrkarehlgrmtsqasgredrmee

    Sequence, based on observed residues (ATOM records):
    >6xp5K (K:)
pvdihkpftpaeriqqlgeidndiasllqhlsaalkalatpdpvtafktaqndffrtidr
idkhltrqiyaleeagiitlksgtgsgagtvgagateeqaqqlpqpq

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6xp5N (N:)
mearahgalpnnydrerfingvggddkalkrkleeplsditkeldtviaqsdvavadpkg
qlcpdadvpdemehitdgilplnlllirlaefshskleelvtmlaskpvpqhavngngsh
stlvedaspesqekkrlllntiqdlhsrwvkalvitewarnaekvgklidirthlfkkle
lypqvlndfinlkrdmawakvpspdlktalhilthgevtwmpdfnfldpppltteetlrw
indmnlalharlqleehdklpppfknytidsgrvtfrvrgefevdlsiseedfseqfwfi
nfrfdfspapaeltpavrywmtekvnnilkteglggcykylheftltqkiaelhrqaial
nkgrwanslrveklnrnlgihywanrlhsqnlkswiiigvhsgedpqgleepkpsylmvq
wfregveqfidipfsqeklsieeilefvtakhvgyllfslfrkfdgkprftqgkkarlel
nvwtqkpedyylsmqllddedlkiqvnpwmgdfittpstgpwnrtlnslgnpaeegskel
enfryiyiisvlkaqgkshgwsvvrspisqdelrsivhsesassretfqaawtrfvdwdp
qwyamrsmslagdqwwlvevtsqrqsisgnrlvfftkmapcfseerltdgffnglrdhsr
rliaeitnlrelypgitpsqlrklidptrqppvlpvkaskilgdfggadaqsiawlkdpv
wliyrgsacdaaatrvsdspqqkrtqpvldvfeayldvtdrrrfqtlnprldrdilynpy
tgrfmfrlrakmgvpvvpllgirvrqlqrlldfleglrrvgdqavpervtlreivfsyga
trkrdstnqpkvrpwrvrldltkeegvgvvlekgnphlrvinrledlvnsqkfyslatyl
tlslplfrafeqlenawqtaqengrgscfilhlsldkhtirfvlpghqrqislliqphek
egklvwevgrprhdpellnencefnrvlkervwtisgsgfkglvtgaaaepdegierllv
lisdavlhlstsqpatappqppqaqpsqqvqqvqqqqvvsqlqpqaqqprsamphasvgq
qqphgapapmarfppqqqqifqqqrppqpqpnmhggqisqpnmhggpkpqlqgqhgqpgq
mvaapqqqgqrpgtgtaagmgrsnaplvvld

    Sequence, based on observed residues (ATOM records):
    >6xp5N (N:)
efshskleelvtmlaskpvpqhavngngshstlpppltteetlrwindmnlalharlqle
ehdklpppfknytidsgrvtfrvrgefevdlsiseedfseqfwfinfrfdfspapaeltp
avrywmtekvnnilkteglggcykylheftltqkiaelhrqaialnkgrwanslrvekln
rnlgihywanrlhsqnlkswiiigvhpsylmvqwfregveqfidipfsqeklsieeilef
vtakhvgyllfslfrkfdgkplelnvwtqkpedyylsmqllddedlkiqvnpwmgdfitt
psrtlnslgnpaeegskelenfryiyiisvlkaqgkshgwsvvrspisqdelrsivhses
assretfqaawtrfvdwdpqyamrsmslatkmapcfseerltdgffnglrdhsrrliaei
tnlrelypgitpsqlrklidptrqppvlaqsiawlkdpvwliyrgsacdaaatrvsdspq
qkrtqpvldvfeayldvtdrrrfqtlnprldrdilynpytgrfmfrlrakmgvpvvpllg
irvr

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >6xp5Q (Q:)
mtdrpfilqvpptqqrgpqniaefvarinpdafrvlneaelrrkveeekngvgqdedvdm
esspsdnegepadakdiitakhemlrvidqtrqttlyaldfvslllskenpgqavttfsp
glrelvgigtlgatmldaptpltqsripdnklvtigkrlmdlnkaadtalaaskrlqkei
aaetkywsevlavrndgwqtsrmprepqtmgvkfgfnnaapefkavsiapmrradngsvl
ldrssighksqriqvriledgrivgrsslpspvsadaplqdrvkemrdtifaqelwhein
reartllnqgvhlepssitytmdasttvsirlatlgeeeegldeqqegpqdvmaeslnia
lslllshahrmnelrrsepginkgpprtypillplisyhkynqsiqtclqtlsahisvlr
sasvdssmtvkepllssppgapaatslytiltrppavqfdititpdsririllkptqltg
aafsicclpalhpgaqnplattcppstddydsltqvvsylqaaipralaahyeavlvvea
tvnggmlgdlppspsrwmplidgkgivdpetmrfgirfsfgrnpakggqlelgaqtdyvd
gsrkrvrrnwiwpgaqssldsvakhvlargppee

    Sequence, based on observed residues (ATOM records):
    >6xp5Q (Q:)
frvlneaelrrkveeekngvgqdedvdmesspsdnegepadakdiitakhemlrvidqtr
qttlyaldfvslllsketigkrlmdlnkaadtalaaskrlqkeiaaetkywsevlavrnd
gwqtsrmprepqtmgvkfgfnnaapefkavsiapmrradngsvlldrssighksqriqvr
iledgrivgrsslpspvsadaplqdrvkemrdtifaqelwheinreartllnqgvhleps
sitytmdasttvsirlatpqdvmaeslnshahrmnelrrsepgipprtypillplisyhk
ynqsiqtclqtlsahisvlrsasvdssmtvtslytiltrppavqfdititpdsririllk
ptqltsicclpalhpgaqnplattcppstddydsltqvvsylqaaipralaahyeavlvd
petmrfgirfsfgrnpakggqlelgaqtdyvdgsrkrvrrnwiwpgaqssldsvak

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6xp5R (R:)
mpyeiflagvvsdndeakaravlggftemrehhrftrvqhyepqdikirgfptikellke
rgpttalyqelhnilvrqpytlqirtnitdailgpaqagaeaaphgtvsggkphilrwsd
ipdppnqrippfitqrkiieipdqraprilaaskfrnksdlveesyhwwfndveysmvrt
ylisldpspqttdqvpslaglepigdfwllyvrmrveatpdrmqqahnqlqqirdqllgv
fefkvwdrrahdtrimeqptqgngnvigdahnsnkksngvspttassseevspvdsqlti
plpddddgdnvedtpdtemdedddeseydsdserdwpkdd

    Sequence, based on observed residues (ATOM records):
    >6xp5R (R:)
pyeiflagvvsdnkaravlggftemirgfptikellkergpqelhnilvrqpdailgpaq
agaeaaphgtvsggkphilrwsdipdppnqrippfitqrkiieipdqraprilaaskfrn
ksdlveesyhwwfndveysmvrtldpspqttdqvpslaglepigdfwllyvrmrveatpd
rmqqahnqlqqirdqllgvfefkvwdr

  • Chain 'U':
    Sequence, based on SEQRES records:
    >6xp5U (U:)
drltqlqeamdellemflsaffwverhhdlktfgpndkipdlkadqpkevdtkspeeyka
gqlqlardiivkeqqieylistlpgldnsereqiqllreleddlvtaeaqrqealkerde
vlgkldallrglerp

    Sequence, based on observed residues (ATOM records):
    >6xp5U (U:)
drltqlqeamdellemflsaffwverhhdlktfgpndkipdlkadtkspeeykagqlqla
rdiivkeqqieylistlpgldnsereqiqllreleddlvtaeaqrqealkerdevlgkld
allrglerp

  • Chain 'V':
    Sequence, based on SEQRES records:
    >6xp5V (V:)
mdrdqgasdnllerkniliasimtsyrdlithatspitsataspghagyssmalstaiha
avkytedllsltrtlrealwvvgpltgpgekdaqaeegmakdaevvwdvlnemrdrerer
mmaalmegdtrvrgavrfergdvevvvagqgqqiemgrgvngevksega

    Sequence, based on observed residues (ATOM records):
    >6xp5V (V:)
erkniliasimtsyrdlithatspitsataspghagyssmalstaihaavkytedllslt
rtlrealwvvgpltgpgekdaqaeegmakdaevvwdvlnemrdrerermmaa

  • Chain 'Z':
    Sequence, based on SEQRES records:
    >6xp5Z (Z:)
msvdssgmeppplpsdgpeepkhgghtrfelelefvqalsnpeyvnwlasrkylmnpafv
ayldylqywsrppylkyltyptatlrmlqllqserfrqeilvpdvawqlrlegmkaavlw
hkeg

    Sequence, based on observed residues (ATOM records):
    >6xp5Z (Z:)
hgghtrfelelefvqalsnpeyvnwlasrkylmnpafvayldlqywsrppylkyltypta
lrmlqllqserfrqeilvpdvawqlrlegmkaavlwhk

  • Chain 'a':
    Sequence, based on SEQRES records:
    >6xp5a (a:)
mstpiptpgrnplqgrtpsqahgaagtppvstpfsaaqavfspngprsspqqfkrspatv
gsttatggrppsainfdspsasaalgalqpmtpgmdmtirslanlgrasederakrleev
ihilskskglvseaglerlarslelefmwessmgsdnkrtlivagsalellvefsqdvvq
svtlnfpdspeivtkhaqkageilfndlrlapgqspltkslarfaanferlavldklsil
pglnlyeavadvyeslarlhawelqklredpslagkddeylenlvlctksgkpamndrgr
vglaldywkekhllrtpeaevaswiadnertwsiligcaplrdlsinpvrisdkwigpnv
vktslpdglhtgepiidwldpeptfipatdqqqqqqqqqqqqqqqqqqqqqadapllppr
lpevafhavfdppvhipinlwqhlqemgcvlpdetatqpfqqhhfrsfdslvipppqgke
tdatetrvfscrkktpfvprrsgvrngegatqkmeyrihqntlfvpkpvmcrtltemsfs
hpqqlvsilpylrqyaflaqllensfkpgpalqlptdpnadtttskptpnakashkkldd
feaflakhsshsgpisnmtpsqhqpssdlsidvtlrlvlpspklqivfplhatskeevkg
kiahvtfavrengrlevemqnmieeegdqmegvktegdedgeekkrrrpqpgdlaralev
ledvgkwaefvrtrwv

    Sequence, based on observed residues (ATOM records):
    >6xp5a (a:)
eevihilskskglvseaglerlarslelefmwkrtlivagsalellvefsqdvvqsvtln
fpdivtkhaqkageilfndlrlapgqspltkslarfaanferlavldklsileavadvye
slarlhawelqklredpslagkddeylenlvlctksgkpamndrgrvglaldyeaevasw
iadnertwsiligcaplrdlsinpvrisdkwigpnvktslpdglhtgepiidwldpeptf
ipatdqqqqqpnadtttskptpnakashkklddfeaflakhsshsgpisnmtpsqhqpss
dlsidvtlrpklqivfplhatskeevkgkiaheegdqmegvktegdedgeekkrrrpqpg
dlaralevledvgkwaefvr

  • Chain 'b':
    Sequence; same for both SEQRES and ATOM records:
    >6xp5b (b:)
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  • Chain 'c':
    Sequence; same for both SEQRES and ATOM records:
    >6xp5c (c:)
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