PDB entry 6xp1

View 6xp1 on RCSB PDB site
Description: Structure of human PYCR1 complexed with L-thiazolidine-2-carboxylate
Class: oxidoreductase
Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Deposited on 2020-07-07, released 2020-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xp1a1, d6xp1a2
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d6xp1b1, d6xp1b2, d6xp1b3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xp1c1, d6xp1c2
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d6xp1d1, d6xp1d2, d6xp1d3
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (21)
    Domains in SCOPe 2.08: d6xp1e1, d6xp1e2, d6xp1e3
  • Heterogens: T2C, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xp1A (A:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp1A (A:)
msvgfigqlafalakgftaagvlaahkimaslatvsalrkmgvkltphnketvqhsdvlf
lavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvv
vregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpayaftalda
ladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatihalhvles
ggfrsllinaveascirtrelqsmad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xp1B (B:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp1B (B:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xp1C (C:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp1C (C:)
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpay
aftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatih
alhvlesggfrsllinaveascirtrelqsmadq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xp1D (D:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp1D (D:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6xp1E (E:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >6xp1E (E:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelqsmadqe