PDB entry 6xl4

View 6xl4 on RCSB PDB site
Description: EGFR(T790M/V948R) in complex with AZD9291 and DDC4002
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: Cancer, Chemotherapy, Kinase inhibitors, Allosteric, TRANSFERASE, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2020-06-28, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6xl4a_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6xl4b_
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6xl4c_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6xl4d_
  • Heterogens: NQ1, Q6K, MG, ANP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xl4A (A:)
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xl4A (A:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakvpikwmalesilhriythq
sdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmid
adsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xl4B (B:)
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xl4B (B:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglavpikwmalesilhriythqs
dvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmida
dsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xl4C (C:)
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xl4C (C:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatankeilde
ayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekkvpikwmalesilhr
iythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrk
cwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmdd
vv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xl4D (D:)
sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
snfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xl4D (D:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrepkankeilde
ayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgavpikwmalesilhriyth
qsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmi
dadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvda