PDB entry 6xiw

View 6xiw on RCSB PDB site
Description: cryo-em structure of the sodium leak channel nalcn-fam155a complex
Deposited on 2020-06-22, released 2020-07-29
The last revision was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: EM
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium leak channel non-selective protein
    Species: Homo sapiens [TaxId:9606]
    Gene: NALCN, VGCNL1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Transmembrane protein FAM155A
    Species: Homo sapiens [TaxId:9606]
    Gene: FAM155A
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, PEV, PGV, Y01, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6xiwA (A:)
    mlkrkqssrveaqpvtdfgpdeslsdnadilwinkpwvhsllricaiisvisvcmntpmt
    fehypplqyvtftldtllmflytaemiakmhirgivkgdssyvkdrwcvfdgfmvfclwv
    slvlqvfeiadivdqmspwgmlriprplimirafriyfrfelprtritnilkrsgeqiws
    vsifllfflllygilgvqmfgtftyhcvvndtkpgnvtwnslaipdthcspeleegyqcp
    pgfkcmdledlglsrqelgysgfneigtsiftvyeaasqegwvflmyraidsfprwrsyf
    yfitlifflawlvknvfiaviietfaeirvqfqqmwgsrssttstattqmfhedaaggwq
    lvavdvnkpqgrapaclqkmmrssvfhmfilsmvtvdvivaasnyykgenfrrqydefyl
    aevaftvlfdleallkiwclgftgyissslhkfelllvigttlhvypdlyhsqftyfqvl
    rvvrlikispaledfvykifgpgkklgslvvftasllivmsaislqmfcfveeldrfttf
    prafmsmfqiltqegwvdvmdqtlnavghmwapvvaiyfilyhlfatlillslfvavild
    nleldedlkklkqlkqseanadtkeklplrlrifekfpnrpqmvkisklpsdftvpkire
    sfmkqfidrqqqdtccllrslpttsssscdhskrsaiednkyidqklrksvfsirarnll
    eketavtkilractrqrmlsgsfegqpakersilsvqhhirqerrslrhgsnsqrisrgk
    sletltqdhsntvryrnaqredseikmiqekkeqaemkrkvqeeelrenhpyfdkplfiv
    grehrfrnfcrvvvrarfnasktdpvtgavkntkyhqlydllglvtyldwvmiivticsc
    ismmfespfrrvmhaptlqiaeyvfvifmsielnlkimadglfftptavirdfggvmdif
    iylvsliflcwmpqnvpaesgaqllmvlrclrplrifklvpqmrkvvrelfsgfkeiflv
    sillltlmlvfasfgvqlfagklakcndpniirredcngifrinvsvsknlnlklrpgek
    kpgfwvprvwanprnfnfdnvgnamlalfevlslkgwvevrdviihrvgpihgiyihvfv
    flgcmigltlfvgvvianfnenkgtalltvdqrrwedlksrlkiaqplhlpprpdndgfr
    akmyditqhpffkrtiallvlaqsvllsvkwdvedpvtvplatmsvvftfifvlevtmki
    iamspagfwqsrrnrydllvtslgvvwvvlhfallnaytymmgacvivfrffsicgkhvt
    lkmllltvvvsmyksffiivgmfllllcyafagvvlfgtvkygeninrhanfssagkait
    vlfrivtgedwnkimhdcmvqppfctpdeftywatdcgnyagalmyfcsfyviiayimln
    llvaiivenfslfysteedqllsyndlrhfqiiwnmvddkregviptfrvkfllrllrgr
    levdldkdkllfkhmcyemerlhnggdvtfhdvlsmlsyrsvdirkslqleellareqle
    ytieeevakqtirmwlkkclkrirakqqqscsiihslresqqqelsrflnppsiettqps
    edtnansqdnsmqpetssqqqllsptlsdrggsrqdaadagkpqrkfgqwrlpsapkpis
    hsvssvnlrfggrttmksvvckmnpmtdaascgsevkkwwtrqltvesdesgddlldigg
    gsggwshpqfekgggsgggsggsawshpqfekgsgdykddddkgnsdykddddk
    

    Sequence, based on observed residues (ATOM records):
    >6xiwA (A:)
    inkpwvhsllricaiisvisvcmntpmtfehypplqyvtftldtllmflytaemiakmhw
    cvfdgfmvfclwvslvlqvfeiadivdqmspwgmlriprplimirafriyfrfelprtri
    tnilkrsgeqiwsvsifllfflllygilgvqmfgtftyhcvvndtkpgnvtwnslaipdt
    hcspeleegyqcppgfkcmdledlglsrqelgysgfneigtsiftvyeaasqegwvflmy
    raidsfprwrsyfyfitlifflawlvknvfiaviietfaeirvqfqqmaclqkmmrssvf
    hmfilsmvtvdvivaasnyykgenfrrqydefylaevaftvlfdleallkiwclgftgyi
    ssslhkfelllvigttlhvypdlyhsqftyfqvlrvvrlikispaledfvykifgpgkkl
    gslvvftasllivmsaislqmfcfveeldrfttfprafmsmfqiltqegwvdvmdqtlna
    vghmwapvvaiyfilyhlfatlillslfvavildnleldedlkklkqlkqsrfrnfcrvv
    vrarfhqlydllglvtyldwvmiivticscismmfespfrrvmhaptlqiaeyvfvifms
    ielnlkimadglfftptavirdfggvmdifiylvsliflcwmpqnvpaesgaqllmvlrc
    lrplrifklvpqmrkvvrelfsgfkeiflvsillltlmlvfasfgvqlfagklakcndpn
    iirredcngifrinvsvsknlnlklrpgekkpgfwvprvwanprnfnfdnvgnamlalfe
    vlslkgwvevrdviihrvgpihgiyihvfvflgcmigltlfvgvvianfnenkgtalltv
    dqrrwedlksrlkiaqplhlpprpdndgfrakmyditqhpffkrtiallvlaqsvllsvk
    wdvedpvtvplatmsvvftfifvlevtmkiiamspagfwqsrrnrydllvtslgvvwvvl
    hfallnaytymmgacvivfrffsicgkhvtlkmllltvvvsmyksffiivgmfllllcya
    fagvvlfgtvkygeninrhanfssagkaitvlfrivtgedwnkimhdcmvqppfctpdef
    tywatdcgnyagalmyfcsfyviiayimlnllvaiivenfslfysteedqllsyndlrhf
    qiiwnmvddkregviptfrvkfllrllrgrlevdldkdkllfkhmcyemerlhnggdvtf
    hdvlsmlsyrsvdirkslqleellareqleytieeevakqtiqscsiihslresqq
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6xiwB (B:)
    mtrgawmcrqyddglkiwlaaprenekpfidseraqkwrlslasllfftvllsdhlwfca
    eakltrardkehqqqqrqqqqqqqqqrqrqqqqqqrrqqepswpallasmgesspaaqah
    rllsasssptlppspgdggggggkgnrgkddrgkalflgnsakpvwrletcypqgassgq
    cftvenadavcarnwsrgaaggdgqevrskhptplwnlsdfylsfcnsytlwelfsglss
    pntlncsldvvlkeggemttcrqcveayqdydhhaqekyeefesvlhkylqseeysvksc
    pedckivykawlcsqyfevtqfncrktipckqyclevqtrcpfilpdndeviygglssfi
    ctglyetfltndepeccdvrreeksnnpskgtveksgschrtsltvssatrlcnsrlklc
    vlvlillhtvltasaaqntaglsfggintleenstneeggsggsdykddddkgnsdykdd
    ddk
    

    Sequence, based on observed residues (ATOM records):
    >6xiwB (B:)
    cypqgnlsdfylsfcnsytlwelfsglcrqcveayqdydhhaqekyeefesvlhkylqse
    eysvkscpedckivykawlcsqyfevtqfncrktipckqyclevqtrcpfilpdndeviy
    gglssfictglyetflepeccdvr