PDB entry 6xg5

View 6xg5 on RCSB PDB site
Description: X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim
Class: oxidoreductase
Keywords: dihydrofolate reductase, dhfr, complex, trimethoprim, oxidoreductase
Deposited on 2020-06-16, released 2021-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Escherichia coli (strain K12) [TaxId:83333]
    Gene: folA, tmrA, b0048, JW0047
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xg5a_
  • Heterogens: TOP, NDP, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xg5A (A:)
misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsycfeilerrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xg5A (A:)
misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsycfeilerr