PDB entry 6xe4

View 6xe4 on RCSB PDB site
Description: BTK Fluorocyclopropyl amide inhibitor, Compound 25
Class: TRANSFERASE/TRANSFERASE Inhibitor
Keywords: kinase, inhibitor, inflammation, drug, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex
Deposited on 2020-06-11, released 2020-07-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-09, with a file datestamp of 2020-09-04.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (Start-265)
      • expression tag (266)
    Domains in SCOPe 2.08: d6xe4a1, d6xe4a2
  • Heterogens: V1G, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xe4A (A:)
mgsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmy
skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
scwhekaderptfkillsnildvmdenlyfqgeeymptehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xe4A (A:)
weidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyles
kqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskf
ssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscw
hekaderptfkillsnildvmden