PDB entry 6xc3

View 6xc3 on RCSB PDB site
Description: Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022
Class: immune system/viral protein
Keywords: Antibody, SARS-CoV-2, Coronavirus, Spike, IMMUNE SYSTEM, IMMUNE SYSTEM-VIRAL PROTEIN complex
Deposited on 2020-06-08, released 2020-07-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: CC12.1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC3 (0-End)
    Domains in SCOPe 2.08: d6xc3a1, d6xc3a2
  • Chain 'B':
    Compound: CC12.1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC3 (0-End)
    Domains in SCOPe 2.08: d6xc3b_
  • Chain 'C':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xc3c_
  • Chain 'H':
    Compound: CR3022 Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC3 (0-221)
    Domains in SCOPe 2.08: d6xc3h_
  • Chain 'L':
    Compound: CR3022 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC3 (0-220)
    Domains in SCOPe 2.08: d6xc3l1, d6xc3l2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xc3A (A:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc3A (A:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xc3B (B:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc3B (B:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xc3C (C:)
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfq
ptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc3C (C:)
nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcft
nvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvnynylyrl
frksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsf
ellhapatvcgpk

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6xc3H (H:)
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetry
spsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6xc3L (L:)
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastr
esgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrgecs