PDB entry 6xc2

View 6xc2 on RCSB PDB site
Description: Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC12.1
Class: immune system/viral protein
Keywords: Antibody, SARS-CoV-2, Coronavirus, Spike, IMMUNE SYSTEM, IMMUNE SYSTEM-VIRAL PROTEIN complex
Deposited on 2020-06-08, released 2020-07-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 3.11 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xc2a_
  • Chain 'H':
    Compound: CC12.1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC2 (0-End)
    Domains in SCOPe 2.08: d6xc2h_
  • Chain 'L':
    Compound: CC12.1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC2 (0-End)
    Domains in SCOPe 2.08: d6xc2l1, d6xc2l2
  • Chain 'X':
    Compound: CC12.1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC2 (0-End)
    Domains in SCOPe 2.08: d6xc2x_
  • Chain 'Y':
    Compound: CC12.1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XC2 (0-End)
    Domains in SCOPe 2.08: d6xc2y1, d6xc2y2
  • Chain 'Z':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xc2z_
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xc2A (A:)
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfq
ptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2A (A:)
nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcft
nvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvnynylyrl
frksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsf
ellhapatvcgpk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6xc2H (H:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2H (H:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6xc2L (L:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2L (L:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >6xc2X (X:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2X (X:)
evqlvesgggliqpggslrlscaasgltvssnymswvrqapgkglewvsviysggstfya
dsvkgrftisrdnskntlylqmnslraedtavyycardldvygldvwgqgttvtvssast
kgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'Y':
    Sequence, based on SEQRES records: (download) 
    >6xc2Y (Y:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2Y (Y:)
divmtqspsflsasvgdrvtitcrasqgissylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqlnsyppkftfgpgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >6xc2Z (Z:)
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfq
ptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xc2Z (Z:)
nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcft
nvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvnynylyrl
frksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsf
ellhapatvcgpk