PDB entry 6xbk

View 6xbk on RCSB PDB site
Description: structure of human smo-g111c/i496c complex with gi
Deposited on 2020-06-06, released 2020-09-30
The last revision was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: EM
Resolution: 3.24 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Smoothened homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: SMO, SMOH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99835
      • engineered mutation (110)
      • engineered mutation (495)
  • Chain 'S':
    Compound: scFv16
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XBK (0-End)
  • Heterogens: CLR

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6xbkA (A:)
mgctlsaedkaaverskmidrnlredgekaarevkllllgagesgkstivkqmkiiheag
yseeeckqykavvysntiqsiiaiiramgrlkidfgdsaraddarqlfvlagaaeegfmt
aelagvikrlwkdsgvqacfnrsreyqlndsaayylndldriaqpnyiptqqdvlrtrvk
ttgivethftfkdlhfkmfdvggqrserkkwihcfegvtaiifcvalsdydlvlaedeem
nrmhesmklfdsicnnkwftdtsiilflnkkdlfeekikksplticypeyagsntyeeaa
ayiqcqfedlnkrkdtkeiythftcatdtknvqfvfdavtdviiknnlkdcglf

    Sequence, based on observed residues (ATOM records):
    >6xbkA (A:)
lsaedkaaverskmidrnlredgekaarevkllllgagesgkstivkqmkgivethftfk
dlhfkmfdvggqrserkkwihcfegvtaiifcvalsdydlvnrmhesmklfdsicnnkwf
tdtsiilflnkkdlfeekikksplticypeyagsntyeeaaayiqcqfedlnkrkdtkei
ythftcatdtknvqfvfdavtdviiknnlkdcglf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6xbkB (B:)
pgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghla
kiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacgg
ldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqq
tttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffp
ngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnv
wdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6xbkB (B:)
dqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhwg
tdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsiy
nlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftght
gdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafatg
sddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadr
agvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6xbkG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6xbkG (G:)
iaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpf

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6xbkR (R:)
maaarpargpelpllglllllllgdpgrgaassgnatgpgprsaggsarrsaavtgpppp
lshcgraapceplrynvclgsvlpygatstllagdsdsqeeahgklvlwsclrnaprcwa
viqpllcavympkcendrvelpsrtlcqatrgpcaiverergwpdflrctpdrfpegctn
evqnikfnssgqcevplvrtdnpkswyedvegcgiqcqnplfteaehqdmhsyiaafgav
tglctlftlatfvadwrnsnrypavilfyvnacffvgsigwlaqfmdgarreivcradgt
mrlgeptsnetlscviifvivyyalmagvvwfvvltyawhtsfkalgttyqplsgktsyf
hlltwslpfvltvailavaqvdgdsvsgicfvgyknyryragfvlapiglvlivggyfli
rgvmtlfsiksnhpgllsekaaskinetmlrlgifgflafgfvlitfschfydffnqaew
ersfrdyvlcqanvtcglptkqpipdceiknrpsllvekinlfamfgtgiamstwvwtka
tlliwrrtwcrltgqsddepkrikkskmiakafskrhellqnpgqelsfsmhtvshdgpv
aglafdlnepsadvssawaqhvtkmvarrgailpqdisvtpvatdykddddk

    Sequence, based on observed residues (ATOM records):
    >6xbkR (R:)
hcgraapceplrynvclgsvlpygatstllagdsdsqeeahgklvlwsclrnaprcwavi
qpllcavympkcendrvelpsrtlcqatrgpcaiverergwpdflrctpdrfpegctnev
qnikfnssgqcevplvrtdnpkswyedvegcgiqcqnplfteaehqdmhsyiaafgavtg
lctlftlatfvadwrnsnrypavilfyvnacffvgsigwlaqfmdgarreivcradgtmr
lgeptsnetlscviifvivyyalmagvvwfvvltyawhtsfkalgttyqplsgktsyfhl
ltwslpfvltvailavaqvdgdsvsgicfvgyknyryragfvlapiglvlivggyflirg
vmtlfsiksnhpgllsekaaskinetmlrlgifgflafgfvlitfschfydffnqaewer
sfrdyvlcqanvtcgdceiknrpsllvekinlfamfgtgiamstwvwt

  • Chain 'S':
    Sequence, based on SEQRES records:
    >6xbkS (S:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
sggggsggggsggggsdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqr
pgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfg
agtklelkaaahhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6xbkS (S:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
sdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsnl
asgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel