PDB entry 6xaf

View 6xaf on RCSB PDB site
Description: 1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H
Class: hydrolase
Keywords: Parkinson's disease, LRRK2, GTPase, Dimer, InterSwitch, complex, HYDROLASE
Deposited on 2020-06-04, released 2021-06-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine-rich repeat serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2, PARK8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5S007
      • engineered mutation (83)
      • engineered mutation (145)
      • engineered mutation (148)
    Domains in SCOPe 2.08: d6xafa_
  • Chain 'B':
    Compound: Leucine-rich repeat serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2, PARK8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5S007
      • engineered mutation (83)
      • engineered mutation (145)
      • engineered mutation (148)
    Domains in SCOPe 2.08: d6xafb_
  • Heterogens: GDP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xafA (A:)
mgsshhhhhhsqdpavpynrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvk
dwpiqirdkrkrdlvlnvwdfagheefysthphfmtqralylavydlskgqaevdamkpw
lfnikarassspvilvgthldvsdeaqraacmskitkellnkrgfpairdyhfvnatees
dalaklrktiineslnfkirdqlvvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xafA (A:)
mklmivgntgsgkttllqqlmkqsatvgidvkdwpiqirdkrkrdlvlnvwdfagheefy
sthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgthldvsdeaqr
aacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfkir

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xafB (B:)
mgsshhhhhhsqdpavpynrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvk
dwpiqirdkrkrdlvlnvwdfagheefysthphfmtqralylavydlskgqaevdamkpw
lfnikarassspvilvgthldvsdeaqraacmskitkellnkrgfpairdyhfvnatees
dalaklrktiineslnfkirdqlvvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6xafB (B:)
rmklmivgntgsgkttllqqlmkqsatvgidvkdwpiqirdkrkrdlvlnvwdfagheef
ysthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgthldvsdeaq
raacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfkird