PDB entry 6x5p

View 6x5p on RCSB PDB site
Description: Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors
Class: blood clotting
Keywords: serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
Deposited on 2020-05-26, released 2020-06-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor ix
    Species: Homo sapiens [TaxId:9606]
    Gene: F9
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00740 (0-End)
      • engineered mutation (137)
    Domains in SCOPe 2.07: d6x5pa_
  • Chain 'B':
    Compound: coagulation factor ix
    Species: Homo sapiens [TaxId:9606]
    Gene: F9
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6x5pb_
  • Heterogens: UQD, CIT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6x5pA (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgasalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt

    Sequence, based on observed residues (ATOM records): (download) 
    >6x5pA (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvevkitvvagehnieete
hteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytniflkf
gsgyvsgwgrvfhkgasalvlqylrvplvdratclrstkftiynnmfcagfheggrdscq
gdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x5pB (B:)
mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtskl
tr

    Sequence, based on observed residues (ATOM records): (download) 
    >6x5pB (B:)
vtcnikngrceqfcknvvcsctegyrlaenqkscepavpfpcgrvsvsq