PDB entry 6x5l
View 6x5l on RCSB PDB site
Description: Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors
Class: blood clotting
Keywords: serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
Deposited on
2020-05-26, released
2020-06-24
The last revision prior to the SCOPe 2.07 freeze date was dated
2020-06-24, with a file datestamp of
2020-06-19.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6x5la_ - Chain 'B':
Compound: coagulation factor ix
Species: Homo sapiens [TaxId:9606]
Gene: F9
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6x5lb_ - Heterogens: UQG, NA, CIT, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6x5lA (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftiynnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektkl
Sequence, based on observed residues (ATOM records): (download)
>6x5lA (A:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvegvkitvvagehnieet
ehteqkrnviriiphhnynaainkynhdialleldeplvlnsyvtpiciadkeytniflk
fgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftiynnmfcagfheggrdsc
qgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektkl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6x5lB (B:)
mdvtcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtskl
tr
Sequence, based on observed residues (ATOM records): (download)
>6x5lB (B:)
vtcnikngrceqfcknvvcsctegyrlaenqkscepavpfpcgrvsvsq