PDB entry 6x5a

View 6x5a on RCSB PDB site
Description: the mouse cgas catalytic domain binding to human nucleosome that purified from hek293t cells
Deposited on 2020-05-25, released 2020-09-16
The last revision was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: EM
Resolution: 4.36 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone H3.2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q71DI3
      • conflict (109)
  • Chain 'B':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Histone H2A type 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Histone H2B type 1-C/E/F/G/I
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Histone H3.2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q71DI3
      • conflict (109)
  • Chain 'F':
    Compound: histone h4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Histone H2A type 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Histone H2B type 1-C/E/F/G/I
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: DNA (natural)
    Species: Homo sapiens [TaxId:9606]
  • Chain 'J':
    Compound: DNA (natural)
    Species: Homo sapiens [TaxId:9606]
  • Chain 'K':
    Compound: Cyclic GMP-AMP synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Cgas, Mb21d1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6x5aA (A:)
artkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkstel
lirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvglfedtnlaaihakrvtim
pkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >6x5aA (A:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeas
eaylvglfedtnlaaihakrvtimpkdiqlarrirger

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6x5aB (B:)
sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >6x5aB (B:)
rdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrktvt
amdvvyalkrqgrtlygfgg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6x5aC (C:)
sgrgkqggkarakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpkkt
eshhkakgk

    Sequence, based on observed residues (ATOM records):
    >6x5aC (C:)
arakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagna
ardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6x5aD (D:)
epaksapapkkgskkavtkaqkkdgkkrkrsrkesysvyvykvlkqvhpdtgisskamgi
mnsfvndiferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtky
tssk

    Sequence, based on observed residues (ATOM records):
    >6x5aD (D:)
krsrkesysvyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrsti
tsreiqtavrlllpgelakhavsegtkavtkytss

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6x5aE (E:)
artkqtarkstggkaprkqlatkaarksapatggvkkphryrpgtvalreirryqkstel
lirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvglfedtnlaaihakrvtim
pkdiqlarrirgera

    Sequence, based on observed residues (ATOM records):
    >6x5aE (E:)
kphryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeas
eaylvglfedtnlaaihakrvtimpkdiqlarrirger

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6x5aF (F:)
sgrgkggkglgkggakrhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkv
flenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg

    Sequence, based on observed residues (ATOM records):
    >6x5aF (F:)
lrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrktv
tamdvvyalkrqgrtlygfgg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6x5aG (G:)
sgrgkqggkarakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleylta
eilelagnaardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavllpkkt
eshhkakgk

    Sequence, based on observed residues (ATOM records):
    >6x5aG (G:)
arakaktrssraglqfpvgrvhrllrkgnyaervgagapvylaavleyltaeilelagna
ardnkktriiprhlqlairndeelnkllgkvtiaqggvlpniqavll

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6x5aH (H:)
epaksapapkkgskkavtkaqkkdgkkrkrsrkesysvyvykvlkqvhpdtgisskamgi
mnsfvndiferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtky
tssk

    Sequence, based on observed residues (ATOM records):
    >6x5aH (H:)
rsrkesysvyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstit
sreiqtavrlllpgelakhavsegtkavtkytss

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6x5aK (K:)
gsefelgsrkepdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveql
ntgsyyehvkisapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflege
vlsatkmlskfrkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilalesk
gswpistkeglpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyil
nnhgiektccessgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdp
qdsqwdprnlsscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkiey
ernngfpifdkl

    Sequence, based on observed residues (ATOM records):
    >6x5aK (K:)
epdklkkvldklrlkrkdiseaaetvnkvverllrrmqkresefkgveqlntgsyyehvk
isapnefdvmfklevprielqeyyetgafylvkfkriprgnplshflegevlsatkmlsk
frkiikeevkeikdidvsvekekpgspavtllirnpeeisvdiilaleskgswpistkeg
lpiqgwlgtkvrtnlrrepfylvpknakdgnsfqgetwrlsfshtekyilnnhgiektcc
essgakccrkeclklmkylleqlkkefqeldafcsyhvktaifhmwtqdpqdsqwdprnl
sscfdkllaffleclrtekldhyfipkfnlfsqelidrkskeflskkieyernngfpifd
kl