PDB entry 6x4q
View 6x4q on RCSB PDB site
Description: Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33)
Class: isomerase/isomerase inhibitor
Keywords: Cyclophilin A, Sanglifehrin A, prolyl isomerase, macrocylcic inhibitor, peptidomimetic, ISOMERASE-ISOMERASE INHIBITOR complex
Deposited on
2020-05-22, released
2020-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-08-26, with a file datestamp of
2020-08-21.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peptidyl-prolyl cis-trans isomerase A
Species: Homo sapiens [TaxId:9606]
Gene: PPIA, CYPA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6x4qa1, d6x4qa2 - Heterogens: UOJ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6x4qA (A:)
ghmvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriip
gfmcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictak
tewldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
Sequence, based on observed residues (ATOM records): (download)
>6x4qA (A:)
hmvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipg
fmcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakt
ewldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgql