PDB entry 6x37

View 6x37 on RCSB PDB site
Description: Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex
Class: transcription
Keywords: Hif2a, Pas B domain, ARNT, hypoxia inducible factor, EPAS1, TRANSCRIPTION
Deposited on 2020-05-21, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endothelial PAS domain-containing protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99814 (5-114)
      • expression tag (2-4)
      • engineered mutation (13)
    Domains in SCOPe 2.08: d6x37a1, d6x37a2
  • Chain 'B':
    Compound: Aryl hydrocarbon receptor nuclear translocator
    Species: Homo sapiens [TaxId:9606]
    Gene: ARNT, BHLHE2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27540 (Start-117)
      • engineered mutation (12)
    Domains in SCOPe 2.08: d6x37b_
  • Heterogens: ULS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6x37A (A:)
gefkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtksh
qnlctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseie

    Sequence, based on observed residues (ATOM records): (download) 
    >6x37A (A:)
fkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtkshqn
lctkgqvvsgqyrmlakhggyvwletqgtviynpqcimcvnyvlseie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x37B (B:)
gefkglnvcqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllr
dsfqqvvklkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvkns

    Sequence, based on observed residues (ATOM records): (download) 
    >6x37B (B:)
cqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrdsfqqvvk
lkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvkns