PDB entry 6x2w

View 6x2w on RCSB PDB site
Description: Crystal Structure of PKINES peptide bound to CRM1(E571K)
Class: protein transport
Keywords: Nuclear export, CRM1, XPO1, Exportin-1, PROTEIN TRANSPORT
Deposited on 2020-05-21, released 2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-12, with a file datestamp of 2020-08-07.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x2wa_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x2wb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (3-End)
      • expression tag (2)
      • conflict (502)
      • conflict (504-506)
      • engineered mutation (547)
      • conflict (987)
  • Chain 'D':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PKIA, PRKACN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61925 (0-14)
      • conflict (0)
  • Heterogens: GNP, MG, GOL

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6x2wA (A:)
maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
alappevvmdpalaaqyehdlevaqttalpdedddl

    Sequence, based on observed residues (ATOM records): (download) 
    >6x2wA (A:)
vqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdtag
qekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdikd
rkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappedp
alaaqyehdlevaqttalpdedddl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x2wB (B:)
dihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkktnk
vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
enadkfkeefekaqeinkka

    Sequence, based on observed residues (ATOM records): (download) 
    >6x2wB (B:)
tmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdktlkican
hiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqei
nkk

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.