PDB entry 6x1g

View 6x1g on RCSB PDB site
Description: Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in complex with Rac1
Class: signaling protein/hydrolase
Keywords: guanine nucleotide exchange factor, GEF, Rac1, GTPase, Orientia tsutsugamushi, scrub typhus, SIGNALING PROTEIN, SIGNALING PROTEIN-HYDROLASE complex
Deposited on 2020-05-18, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ULP_PROTEASE domain-containing protein
    Species: Orientia tsutsugamushi [TaxId:334380]
    Gene: OTT_1962
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3CVM3 (1-212)
      • initiating methionine (0)
      • expression tag (213-215)
  • Chain 'B':
    Compound: ras-related c3 botulinum toxin substrate 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAC1, TC25, MIG5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63000 (0-176)
      • expression tag (177)
    Domains in SCOPe 2.08: d6x1gb1, d6x1gb2
  • Chain 'C':
    Compound: ULP_PROTEASE domain-containing protein
    Species: Orientia tsutsugamushi [TaxId:334380]
    Gene: OTT_1962
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3CVM3 (1-212)
      • initiating methionine (0)
      • expression tag (213-215)
  • Chain 'D':
    Compound: ras-related c3 botulinum toxin substrate 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAC1, TC25, MIG5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63000 (0-176)
      • expression tag (177)
    Domains in SCOPe 2.08: d6x1gd1, d6x1gd2
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x1gB (B:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavlhhh
hhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6x1gB (B:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavlh

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6x1gD (D:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavlhhh
hhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6x1gD (D:)
mqaikcvvvgdgavgktcllisyttnafpgeyiptvfdnysanvmvdgkpvnlglwdtag
qedydrlrplsypqtdvflicfslvspasfenvrakwypevrhhcpntpiilvgtkldlr
ddkdtieklkekkltpitypqglamakeigavkylecsaltqrglktvfdeairavlh