PDB entry 6x19

View 6x19 on RCSB PDB site
Description: Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Class: membrane protein
Keywords: G-coupled protein receptor, GPCR, MEMBRANE PROTEIN, non-peptide agonist
Deposited on 2020-05-18, released 2020-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: EM
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63092 (Start-393)
      • conflict (53)
      • conflict (225)
      • conflict (267)
      • conflict (270)
      • conflict (273)
      • conflict (279)
      • conflict (283-284)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x19b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x19g_
  • Chain 'N':
    Compound: Nanobody35
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X19 (0-End)
    Domains in SCOPe 2.08: d6x19n1, d6x19n2
  • Chain 'R':
    Compound: Glucagon-like peptide 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: GLP1R
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43220
      • conflict (268)
  • Heterogens: UK1, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x19B (B:)
qseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6x19B (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6x19G (G:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

    Sequence, based on observed residues (ATOM records): (download) 
    >6x19G (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6x19N (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >6x19N (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtv

  • Chain 'R':
    No sequence available.