PDB entry 6wxu

View 6wxu on RCSB PDB site
Description: cryoem structure of mouse duox1-duoxa1 complex in the dimer-of-dimer state
Deposited on 2020-05-12, released 2020-09-02
The last revision was dated 2021-03-17, with a file datestamp of 2021-03-12.
Experiment type: EM
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual oxidase 1
    Species: Mus musculus [TaxId:10090]
    Gene: Duox1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Dual oxidase maturation factor 1
    Species: Mus musculus [TaxId:10090]
    Gene: Duoxa1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Dual oxidase 1
    Species: Mus musculus [TaxId:10090]
    Gene: Duox1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Dual oxidase maturation factor 1
    Species: Mus musculus [TaxId:10090]
    Gene: Duoxa1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HEC, MAN, NAG, PX2, PLC

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wxuA (A:)
gpsrgaqnsiswevqrfdgwynnlmehrwgskgsrlqrlvpasyadgvyqplkepylpnp
rhlsnrvmrgsagqpslrnrtvlgvffgyhvlsdlvsvetpgcpaeflniyiphgdpvfd
pdkrgnvvlpfqrsrwdrntgqspsnprdqsnqvtgwldgsaiygsshswsdtlrsfsgg
qlasgpdpafpsdsqssllmwmapdpstgqggprgvyafgaqrgnrepflqalgllwfry
hnlcarklaqehphwgdeelfqharkrviatyqniamyewlpsflkqtppeypgyrpfld
psispefvvaseqflstmvpsgvymrnaschfqgipshnssvsgalrvcnsywsrehpkl
qraedvdalllgmasqiaeredhvvvedmqdfwpgplkfsrtdylasclqrgrdlglpsy
tkarealglspishwqdinpalsrsngtvleataalynqdlsrlellpgglleshgdpgp
lfstivldqfvrlrdgdrywfentrnglfskeeiaeirntslrdilvavtnvdpsalqpn
vffwlagdpcpqpsqlsakglpacaplfirdyfegsgfgfgltigtlccfplvsllsawi
varlrkrnfkrlqrqdrqsimseklvggvealewqgrnepcrpvlvhlqpgqirvvdgrl
tvlrtiqlrppqqvnlilssnrgrrtlllkipkeydlvllfnmeeerqalvenvrgalke
nglsfqewelreqelmraavtrqqrghlletffrhlfsqvldinqadagtlpldsstkvr
ealtcelsraefadslglkpqdmfvesmfsladkdgngylsfrefldilvvfmkgspeek
srlmfrmydfdgngliskdefirmlrsfieisnnclskaqlaevvesmfresgfqdkeel
twedfhfmlrdhdsdlrftqlcvkgvevpeviknlcrrasyisqekicpsprmsahcarn
nmktasspqrlqcpmdtdppqeirrrfgkkvtsfqpllfteahrekfqrsrrhqtvqqfk
rfienyrrhigcvavfytitgalflerayyyafaahhsgitdttrvgiilsrgtaasisf
mfsyilltmcrnlitflretflnryipfdaavdfhrliastaiiltvlhsaghvvnvylf
sisplsvlsclfpglfhddgsefpqkyywwffqtvpgltgvllllalaimyvfashhfrr
rsfrgfwlthhlyiflyilliihgsfaliqmprfhifflvpaiiyvgdklvslsrkkvei
svvkaellpsgvthlrfqrpqgfeyksgqwvriaclalgtteyhpftltsaphedtlslh
iraagpwttrlreiyspptgdtcarypklyldgpfgeghqewhkfevsvlvgggigvtpf
asilkdlvfkssvscqvfckkiyfiwvtrtqrqfewladiireveendrqdlvsvhiyit
qlaekfdlrttmlyicerhfqkvlnrslftglrsithfgrppfepffnslqevhpqvrki
gvfscgppgmtknvekacqlinrqdrthfshhyenf

    Sequence, based on observed residues (ATOM records):
    >6wxuA (A:)
nsiswevqrfdgwynnlmehrwgskgsrlqrlvpasyadgvyqplkepylpnprhlsnrv
mrgsagqpslrnrtvlgvffgyhvlsdlvsvetpgcpaeflniyiphgdpvfdpdkrgnv
vlpfqrsrwdrntgqspsnprdqsnqvtgwldgsaiygsshswsdtlrsfsggqlasgpd
pafpsdsqssllmwmapdpstgqggprgvyafgaqrgnrepflqalgllwfryhnlcark
laqehphwgdeelfqharkrviatyqniamyewlpsflkqtppeypgyrpfldpsispef
vvaseqflstmvpsgvymrnaschfqgisgalrvcnsywsrehpklqraedvdalllgma
sqiaeredhvvvedmqdfwpgplkfsrtdylasclqrgrdlglpsytkarealglspish
wqdinpalsrsngtvleataalynqdlsrlellpgglleshgdpgplfstivldqfvrlr
dgdrywfentrnglfskeeiaeirntslrdilvavtnvdpsalqpnvffwlagdpcpqps
qlsakglpacaplfirdyfegsgfgfgltigtlccfplvsllsawivarlrkrtvqqfkr
fienyrrhigcvavfytitgalflerayyyafaahhsgitdttrvgiilsrgtaasisfm
fsyilltmcrnlitflretflnryipfdaavdfhrliastaiiltvlhsaghvvnvylfs
isplsvlsclfpglfhddgsefpqkyywwffqtvpgltgvllllalaimyvfashhfrrr
sfrgfwlthhlyiflyilliihgsfaliqmprfhifflvpaiiyvgdklvslsr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wxuB (B:)
maalghtlpfytgtkptfpmdttlaviitifltalvtfiiilpgirgktrlfwllrvvts
lfigavilavnfssewsvghvnanttykafspkwvsvdvglqiglggvnitltgtpvqql
netinyneafawrlgrsyaeeyakalekglpdpvlylaekftprspcglynqyrlaghya
samlwvaflcwllanvmlsmpvlvygghmllatglfqllalfffsmttslispcplrlgt
avlhthhgpafwitlatgllcillglvmavahrmqphrlkaffnqssedpvlewgseegg
llsphyrsiaespetqdipmsvassetcfkeehpkesdcsl

    Sequence, based on observed residues (ATOM records):
    >6wxuB (B:)
alghtlpfytgtkptfpmdttlaviitifltalvtfiiilpgirgktrlfwllrvvtslf
igavilavnfssewsvghvnanttykafspkwvsvdvglqiglggvnitltgtpvqqlne
tinyneafawrlgrsyaeeyakalekglpdpvlylaekftprspcglynqyrlaghyasa
mlwvaflcwllanvmlsmpvlvygghmllatglfqllalfffsmttslispcplrlgtav
lhthhgpafwitlatgllcillglvmavahrmq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wxuC (C:)
gpsrgaqnsiswevqrfdgwynnlmehrwgskgsrlqrlvpasyadgvyqplkepylpnp
rhlsnrvmrgsagqpslrnrtvlgvffgyhvlsdlvsvetpgcpaeflniyiphgdpvfd
pdkrgnvvlpfqrsrwdrntgqspsnprdqsnqvtgwldgsaiygsshswsdtlrsfsgg
qlasgpdpafpsdsqssllmwmapdpstgqggprgvyafgaqrgnrepflqalgllwfry
hnlcarklaqehphwgdeelfqharkrviatyqniamyewlpsflkqtppeypgyrpfld
psispefvvaseqflstmvpsgvymrnaschfqgipshnssvsgalrvcnsywsrehpkl
qraedvdalllgmasqiaeredhvvvedmqdfwpgplkfsrtdylasclqrgrdlglpsy
tkarealglspishwqdinpalsrsngtvleataalynqdlsrlellpgglleshgdpgp
lfstivldqfvrlrdgdrywfentrnglfskeeiaeirntslrdilvavtnvdpsalqpn
vffwlagdpcpqpsqlsakglpacaplfirdyfegsgfgfgltigtlccfplvsllsawi
varlrkrnfkrlqrqdrqsimseklvggvealewqgrnepcrpvlvhlqpgqirvvdgrl
tvlrtiqlrppqqvnlilssnrgrrtlllkipkeydlvllfnmeeerqalvenvrgalke
nglsfqewelreqelmraavtrqqrghlletffrhlfsqvldinqadagtlpldsstkvr
ealtcelsraefadslglkpqdmfvesmfsladkdgngylsfrefldilvvfmkgspeek
srlmfrmydfdgngliskdefirmlrsfieisnnclskaqlaevvesmfresgfqdkeel
twedfhfmlrdhdsdlrftqlcvkgvevpeviknlcrrasyisqekicpsprmsahcarn
nmktasspqrlqcpmdtdppqeirrrfgkkvtsfqpllfteahrekfqrsrrhqtvqqfk
rfienyrrhigcvavfytitgalflerayyyafaahhsgitdttrvgiilsrgtaasisf
mfsyilltmcrnlitflretflnryipfdaavdfhrliastaiiltvlhsaghvvnvylf
sisplsvlsclfpglfhddgsefpqkyywwffqtvpgltgvllllalaimyvfashhfrr
rsfrgfwlthhlyiflyilliihgsfaliqmprfhifflvpaiiyvgdklvslsrkkvei
svvkaellpsgvthlrfqrpqgfeyksgqwvriaclalgtteyhpftltsaphedtlslh
iraagpwttrlreiyspptgdtcarypklyldgpfgeghqewhkfevsvlvgggigvtpf
asilkdlvfkssvscqvfckkiyfiwvtrtqrqfewladiireveendrqdlvsvhiyit
qlaekfdlrttmlyicerhfqkvlnrslftglrsithfgrppfepffnslqevhpqvrki
gvfscgppgmtknvekacqlinrqdrthfshhyenf

    Sequence, based on observed residues (ATOM records):
    >6wxuC (C:)
nsiswevqrfdgwynnlmehrwgskgsrlqrlvpasyadgvyqplkepylpnprhlsnrv
mrgsagqpslrnrtvlgvffgyhvlsdlvsvetpgcpaeflniyiphgdpvfdpdkrgnv
vlpfqrsrwdrntgqspsnprdqsnqvtgwldgsaiygsshswsdtlrsfsggqlasgpd
pafpsdsqssllmwmapdpstgqggprgvyafgaqrgnrepflqalgllwfryhnlcark
laqehphwgdeelfqharkrviatyqniamyewlpsflkqtppeypgyrpfldpsispef
vvaseqflstmvpsgvymrnaschfqgisgalrvcnsywsrehpklqraedvdalllgma
sqiaeredhvvvedmqdfwpgplkfsrtdylasclqrgrdlglpsytkarealglspish
wqdinpalsrsngtvleataalynqdlsrlellpgglleshgdpgplfstivldqfvrlr
dgdrywfentrnglfskeeiaeirntslrdilvavtnvdpsalqpnvffwlagdpcpqps
qlsakglpacaplfirdyfegsgfgfgltigtlccfplvsllsawivarlrkrtvqqfkr
fienyrrhigcvavfytitgalflerayyyafaahhsgitdttrvgiilsrgtaasisfm
fsyilltmcrnlitflretflnryipfdaavdfhrliastaiiltvlhsaghvvnvylfs
isplsvlsclfpglfhddgsefpqkyywwffqtvpgltgvllllalaimyvfashhfrrr
sfrgfwlthhlyiflyilliihgsfaliqmprfhifflvpaiiyvgdklvslsr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6wxuD (D:)
maalghtlpfytgtkptfpmdttlaviitifltalvtfiiilpgirgktrlfwllrvvts
lfigavilavnfssewsvghvnanttykafspkwvsvdvglqiglggvnitltgtpvqql
netinyneafawrlgrsyaeeyakalekglpdpvlylaekftprspcglynqyrlaghya
samlwvaflcwllanvmlsmpvlvygghmllatglfqllalfffsmttslispcplrlgt
avlhthhgpafwitlatgllcillglvmavahrmqphrlkaffnqssedpvlewgseegg
llsphyrsiaespetqdipmsvassetcfkeehpkesdcsl

    Sequence, based on observed residues (ATOM records):
    >6wxuD (D:)
alghtlpfytgtkptfpmdttlaviitifltalvtfiiilpgirgktrlfwllrvvtslf
igavilavnfssewsvghvnanttykafspkwvsvdvglqiglggvnitltgtpvqqlne
tinyneafawrlgrsyaeeyakalekglpdpvlylaekftprspcglynqyrlaghyasa
mlwvaflcwllanvmlsmpvlvygghmllatglfqllalfffsmttslispcplrlgtav
lhthhgpafwitlatgllcillglvmavahrmq