PDB entry 6wx8

View 6wx8 on RCSB PDB site
Description: SOX2 bound to Importin-alpha 3
Class: nuclear protein
Keywords: nuclear protein
Deposited on 2020-05-10, released 2020-10-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Importin subunit alpha-3
    Species: Homo sapiens [TaxId:9606]
    Gene: KPNA4, QIP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6wx8a_
  • Chain 'B':
    Compound: transcription factor sox-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SOX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6wx8b_
  • Chain 'C':
    Compound: Importin subunit alpha-3
    Species: Homo sapiens [TaxId:9606]
    Gene: KPNA4, QIP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6wx8c_
  • Chain 'D':
    Compound: transcription factor sox-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SOX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6wx8d_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wx8A (A:)
sgdyrvqntsleaivqnassdnqgiqlsavqaarkllssdrnppiddliksgilpilvhc
lerddnpslqfeaawaltniasgtseqtqavvqsnavplflrllhsphqnvceqavwalg
niigdgpqcrdyvislgvvkpllsfispsipitflrnvtwvmvnlcrhkdppppmetiqe
ilpalcvlihhtdvnilvdtvwalsyltdagneqiqmvidsgivphlvpllshqevkvqt
aalravgnivtgtdeqtqvvlncdalshfpallthpkekinkeavwflsnitagnqqqvq
avidanlvpmiihlldkgdfgtqkeaawaisnltisgrkdqvayliqqnvippfcnlltv
kdaqvvqvvldglsnilkmaedeaetignlieecgglekieqlqnhenediyklayeiid
qffssddidedpslvpeaiqggtfgfnssanvptegfqf

    Sequence, based on observed residues (ATOM records): (download) 
    >6wx8A (A:)
rvqntsleaivqnassdnqgiqlsavqaarkllssdrnppiddliksgilpilvhclerd
dnpslqfeaawaltniasgtseqtqavvqsnavplflrllhsphqnvceqavwalgniig
dgpqcrdyvislgvvkpllsfispsipitflrnvtwvmvnlcrhkdppppmetiqeilpa
lcvlihhtdvnilvdtvwalsyltdagneqiqmvidsgivphlvpllshqevkvqtaalr
avgnivtgtdeqtqvvlncdalshfpallthpkekinkeavwflsnitagnqqqvqavid
anlvpmiihlldkgdfgtqkeaawaisnltisgrkdqvayliqqnvippfcnlltvkdaq
vvqvvldglsnilkmaedeaetignlieecgglekieqlqnhenediyklayeiidqff

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wx8B (B:)
sdrvkrpmnafmvwsrgqrrkmaqenpkmhnseiskrlgaewkllsetekrpfideakrl
ralhmkehpdykyrprrktktlmkkdkytl

    Sequence, based on observed residues (ATOM records): (download) 
    >6wx8B (B:)
drvkrpmnafmvwsrgqrrkmaqenpkmhnseiskrlgaewkllsetekrpfideakrlr
alhmkehpdykyrprrktktlm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6wx8C (C:)
sgdyrvqntsleaivqnassdnqgiqlsavqaarkllssdrnppiddliksgilpilvhc
lerddnpslqfeaawaltniasgtseqtqavvqsnavplflrllhsphqnvceqavwalg
niigdgpqcrdyvislgvvkpllsfispsipitflrnvtwvmvnlcrhkdppppmetiqe
ilpalcvlihhtdvnilvdtvwalsyltdagneqiqmvidsgivphlvpllshqevkvqt
aalravgnivtgtdeqtqvvlncdalshfpallthpkekinkeavwflsnitagnqqqvq
avidanlvpmiihlldkgdfgtqkeaawaisnltisgrkdqvayliqqnvippfcnlltv
kdaqvvqvvldglsnilkmaedeaetignlieecgglekieqlqnhenediyklayeiid
qffssddidedpslvpeaiqggtfgfnssanvptegfqf

    Sequence, based on observed residues (ATOM records): (download) 
    >6wx8C (C:)
ntsleaivqnassdnqgiqlsavqaarkllssdrnppiddliksgilpilvhclerddnp
slqfeaawaltniasgtseqtqavvqsnavplflrllhsphqnvceqavwalgniigdgp
qcrdyvislgvvkpllsfispsipitflrnvtwvmvnlcrhkdppppmetiqeilpalcv
lihhtdvnilvdtvwalsyltdagneqiqmvidsgivphlvpllshqevkvqtaalravg
nivtgtdeqtqvvlncdalshfpallthpkekinkeavwflsnitagnqqqvqavidanl
vpmiihlldkgdfgtqkeaawaisnltisgrkdqvayliqqnvippfcnlltvkdaqvvq
vvldglsnilkmaedeaetignlieecgglekieqlqnhenediyklayeiidqffs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6wx8D (D:)
sdrvkrpmnafmvwsrgqrrkmaqenpkmhnseiskrlgaewkllsetekrpfideakrl
ralhmkehpdykyrprrktktlmkkdkytl

    Sequence, based on observed residues (ATOM records): (download) 
    >6wx8D (D:)
rvkrpmnafmvwsrgqrrkmaqenpkmhnseiskrlgaewkllsetekrpfideakrlra
lhmkehpdykyrprrktktlm