PDB entry 6wwz

View 6wwz on RCSB PDB site
Description: cryo-em structure of the human chemokine receptor ccr6 in complex with ccl20 and a go protein
Deposited on 2020-05-09, released 2020-06-24
The last revision was dated 2020-07-01, with a file datestamp of 2020-06-26.
Experiment type: EM
Resolution: 3.34 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(o) subunit alpha,Guanine nucleotide-binding protein G(o) subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAO1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09471
      • conflict (53-54)
    • Uniprot P09471 (77-249)
      • conflict (122)
      • conflict (125)
      • conflict (145)
      • conflict (227)
      • conflict (230)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: C-C motif chemokine 20
    Species: Homo sapiens [TaxId:9606]
    Gene: CCL20, LARC, MIP3A, SCYA20
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: C-C chemokine receptor type 6,C-C chemokine receptor type 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CCR6, CKRL3, CMKBR6, GPR29, STRL22
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: scFv16
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WWZ
  • Chain 'Y':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WWZ

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wwzA (A:)
mghhhhhhenlyfqgtlsaeeraalerskaieknlkedgisaakdvkllllgadnsgkst
ivkqmkiihggsggsggttgivethftfknlhfrlfdvggqrserkkwihcfedvtaiif
cvdlsdydqvlhedettnrmheslmdfdsicnnkffidtsiilflnkkdlfgekikkspl
ticfpeytgpntyedaaayiqaqfesknrspnkeiychmtcatdtnnaqvifdavtdiii
annlrgcgly

    Sequence, based on observed residues (ATOM records):
    >6wwzA (A:)
lsaeeraalerskaieknlkedgisaakdvkllllgadnsgkstivkttgivethftfkn
lhfrlfdvggqrserkkwihcfedvtaiifcvdlsdynrmheslmdfdsicnnkffidts
iilflnkkdlfgekikksplticfpeytgpntyedaaayiqaqfesknrspnkeiychmt
catdtnnaqvifdavtdiiiannlrgcgly

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wwzB (B:)
mhhhhhhgsllqseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrr
tlrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsg
nyvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalw
dietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdi
naicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagy
ddfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6wwzB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wwzC (C:)
asnfdcclgytdrilhpkfivgftrqlanegcdinaiifhtkkklsvcanpkqtwvkyiv
rllskkvknm

    Sequence, based on observed residues (ATOM records):
    >6wwzC (C:)
asnfdcclgytdrilhpkfivgftrqlanegcdinaiifhtkkklsvcanpkqtwvkyiv
rllskk

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6wwzR (R:)
mktiialsyifclvfadykddddaklqtmgtadlednwetlndnlkviekadnaaqvkda
ltkmraaaldaqkatppkledkspdspemkdfrhgfdilvgqiddalklanegkvkeaqa
aaeqlkttrnayiqkylgsenlyfqgsgesmnfsdvfdssedyfvsvntsyysvdsemll
cslqevrqfsrlfvpiayslicvfgllgnilvvitfafykkarsmtdvyllnmaiadilf
vltlpfwavshatgawvfsnatckllkgiyainfncgmllltcismdryiaivqatksfr
lrsrtlprskiiclvvwglsviissstfvfnqkyntqgsdvcepkyqtvsepirwkllml
glellfgffiplmfmifcytfivktlvqaqnskrhkairviiavvlvflacqiphnmvll
vtaanlgkmnrscqsekligytktvtevlaflhcclnpvlyafigqkfrnyflkilkdlw
cvrrkykssgfscagrysenisrqtsetadndnassftmhhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6wwzR (R:)
ysvdsemllcslqevrqfsrlfvpiayslicvfgllgnilvvitfafykkarsmtdvyll
nmaiadilfvltlpfwavshatgawvfsnatckllkgiyainfncgmllltcismdryia
ivqatksfrlrsrtlprskiiclvvwglsviissstfvfnqkyntqgsdvcepkyqtvse
pirwkllmlglellfgffiplmfmifcytfivktlvqaqnskrhkairviiavvlvflac
qiphnmvllvtaanlgkmnrscqsekligytktvtevlaflhcclnpvlyafigqkfrny
flkilkdlwc

  • Chain 'S':
    Sequence, based on SEQRES records:
    >6wwzS (S:)
metdtlllwvlllwvpgstgdvqlvesggglvqpggsrklscsasgfafssfgmhwvrqa
pekglewvayissgsgtiyyadtvkgrftisrddpkntlflqmtslrsedtamyycvrsi
yyygsspfdfwgqgttltvssggggsggggsggggsdivmtqatssvpvtpgesvsiscr
ssksllhsngntylywflqrpgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrle
aedvgvyycmqhleypltfgagtklelkaaalevlfqgphhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6wwzS (S:)
vqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyya
dtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvss
divmtqatssvpvtpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsnla
sgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel

  • Chain 'Y':
    Sequence, based on SEQRES records:
    >6wwzY (Y:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffc

    Sequence, based on observed residues (ATOM records):
    >6wwzY (Y:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre