PDB entry 6wvz

View 6wvz on RCSB PDB site
Description: Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET
Class: Transferase/Immune System
Keywords: ANTIGEN-FAB COMPLEX, SEMAPHORIN DOMAIN, PLEXIN SEMAPHORIN INTEGRIN CYSTEINE-RICH DOMAIN, ANTITUMOR PROTEIN, Transferase-Immune System complex
Deposited on 2020-05-07, released 2021-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Heavy Chain of anti-MET Fab of amivantamab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WVZ (0-227)
    Domains in SCOPe 2.08: d6wvzh_
  • Chain 'L':
    Compound: Light Chain of anti-MET Fab of amivantamab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WVZ (0-213)
    Domains in SCOPe 2.08: d6wvzl1, d6wvzl2
  • Chain 'M':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581 (0-525)
      • expression tag (526-533)
    Domains in SCOPe 2.08: d6wvzm1, d6wvzm2, d6wvzm3
  • Heterogens: NAG, FMT, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6wvzH (H:)
qvqlvqsgaevkkpgasvkvscetsgytftsygiswvrqapghglewmgwisayngytny
aqklqgrvtmttdtststaymelrslrsddtavyycardlrgtnyfdywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkschhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6wvzH (H:)
qvqlvqsgaevkkpgasvkvscetsgytftsygiswvrqapghglewmgwisayngytny
aqklqgrvtmttdtststaymelrslrsddtavyycardlrgtnyfdywgqgtlvtvssa
stkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkrvepksc

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6wvzL (L:)
diqmtqspssvsasvgdrvtitcrasqgisnwlawfqhkpgkapklliyaassllsgvps
rfsgsgsgtdftltisslqpedfatyycqqansfpitfgqgtrleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6wvzL (L:)
diqmtqspssvsasvgdrvtitcrasqgisnwlawfqhkpgkapklliyaassllsgvps
rfsgsgsgtdftltisslqpedfatyycqqansfpitfgqgtrleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6wvzM (M:)
mkyqlpnftaetpiqnvilhehhiflgatnyiyvlneedlqkvaeyktgpvlehpdcfpc
qdcsskanlsggvwkdninmalvvdtyyddqliscgsvnrgtcqrhvfphnhtadiqsev
hcifspqieepsqcpdcvvsalgakvlssvkdrfinffvgntinssyfpdhplhsisvrr
lketkdgfmfltdqsyidvlpefrdsypikyvhafesnnfiyfltvqretldaqtfhtri
irfcsinsglhsymempleciltekrkkrstkkevfnilqaayvskpgaqlarqigasln
ddilfgvfaqskpdsaepmdrsamcafpikyvndffnkivnknnvrclqhfygpnhehcf
nrtllrnssgcearrdeyrtefttalqrvdlfmgqfsevlltsistfikgdltianlgts
egrfmqvvvsrsgpstphvnflldshpvspevivehtlnqngytlvitgkkitkiplngl
gcrhfqscsqclsappfvqcgwchdkcvrseeclsgtwtqqiclpahhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6wvzM (M:)
kyqlpnftaetpiqnvilhehhiflgatnyiyvlneedlqkvaeyktgpvlehpdcfpcq
dcsskanlsggvwkdninmalvvdtyyddqliscgsvnrgtcqrhvfphnhtadiqsevh
cifspqieepsqcpdcvvsalgakvlssvkdrfinffvgntinssyfpdhplhsisvrrl
ketkdgfmfltdqsyidvlpefrdsypikyvhafesnnfiyfltvqretldaqtfhtrii
rfcsinsglhsymempleciltekkevfnilqaayvskpgaqlarqigaslnddilfgvf
aqskpdsaepmdrsamcafpikyvndffnkivnknnvrclqhfygpnhehcfnrtllrns
gcearrdeyrtefttalqrvdlfmgqfsevlltsistfikgdltianlgtsegrfmqvvv
srsgpstphvnflldshpvspevivehtlnqngytlvitgkkitkiplnglgcrhfqscs
qclsappfvqcgwchdkcvrseeclsgtwtqqiclpah