PDB entry 6wvw

View 6wvw on RCSB PDB site
Description: Crystal structure of the R59P-SNAP25 containing SNARE complex
Class: exocytosis
Keywords: SNARE complex, synaptic vesicle fusion, EXOCYTOSIS
Deposited on 2020-05-07, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-17, with a file datestamp of 2021-03-12.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: vesicle-associated membrane protein 2
  Species: Rattus norvegicus [TaxId:10116]
  Gene: Vamp2, Syb2
  Database cross-references and differences (RAF-indexed):
  • Uniprot P63045 (1-62)
  Domains in SCOPe 2.08: d6wvwa_
• Chain 'B':
  Compound: syntaxin-1a
  Species: Rattus norvegicus [TaxId:10116]
  Gene: Stx1a, Sap
  Database cross-references and differences (RAF-indexed):
  • Uniprot P32851 (0-65)
  Domains in SCOPe 2.08: d6wvwb_
• Chain 'C':
  Compound: synaptosomal-associated protein 25
  Species: Rattus norvegicus [TaxId:10116]
  Gene: SNAP25, SNAP
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60881 (Start-73)
    • engineered mutation (49)
  Domains in SCOPe 2.08: d6wvwc_
• Chain 'D':
  Compound: synaptosomal-associated protein 25
  Species: Rattus norvegicus [TaxId:10116]
  Gene: SNAP25, SNAP
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60881 (0-End)
  Domains in SCOPe 2.08: d6wvwd_
• Chain 'E':
  Compound: vesicle-associated membrane protein 2
  Species: Rattus norvegicus [TaxId:10116]
  Gene: Vamp2, Syb2
  Database cross-references and differences (RAF-indexed):
  • Uniprot P63045 (1-62)
    • expression tag (0)
  Domains in SCOPe 2.08: d6wvwe1, d6wvwe2
• Chain 'F':
  Compound: syntaxin-1a
  Species: Rattus norvegicus [TaxId:10116]
  Gene: Stx1a, Sap
  Database cross-references and differences (RAF-indexed):
  • Uniprot P32851 (0-65)
  Domains in SCOPe 2.08: d6wvwf_
• Chain 'G':
  Compound: synaptosomal-associated protein 25
  Species: Rattus norvegicus [TaxId:10116]
  Gene: SNAP25, SNAP
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60881 (0-73)
    • engineered mutation (49)
  Domains in SCOPe 2.08: d6wvwg_
• Chain 'H':
  Compound: synaptosomal-associated protein 25
  Species: Rattus norvegicus [TaxId:10116]
  Gene: SNAP25, SNAP
  Database cross-references and differences (RAF-indexed):
  • Uniprot P60881 (Start-63)
  Domains in SCOPe 2.08: d6wvwh_
• Heterogens: MPD, CA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >6wvwA (A:)
  gsnrrlqqtqaqvdevvdimrvnvdkvlerdqklselddradalqagasqfetsaaklkr
  kyw
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6wvwA (A:)
  snrrlqqtqaqvdevvdimrvnvdkvlerdqklselddradalqagasqfetsaaklkrk
  yw
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6wvwB (B:)
  alseietrhseiiklensirelhdmfmdmamlvesqgemidrieynvehavdyveravsd
  tkkavk
  

  
  
• Chain 'C':
  Sequence, based on SEQRES records: (download)
  

  >6wvwC (C:)
  eleemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldpveegmnhinq
  dmkeaeknlkdlgk
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6wvwC (C:)
  leemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldpveegmnhinqd
  mkeaeknlkdlgk
  

  
  
• Chain 'D':
  Sequence, based on SEQRES records: (download)
  

  >6wvwD (D:)
  arenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqrat
  kmlg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6wvwD (D:)
  arenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqrat
  kml
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6wvwE (E:)
  gsnrrlqqtqaqvdevvdimrvnvdkvlerdqklselddradalqagasqfetsaaklkr
  kyw
  

  
  
• Chain 'F':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6wvwF (F:)
  alseietrhseiiklensirelhdmfmdmamlvesqgemidrieynvehavdyveravsd
  tkkavk
  

  
  
• Chain 'G':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6wvwG (G:)
  eleemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldpveegmnhinq
  dmkeaeknlkdlgk
  

  
  
• Chain 'H':
  Sequence, based on SEQRES records: (download)
  

  >6wvwH (H:)
  arenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqrat
  kmlg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >6wvwH (H:)
  enemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqratkm
  lg