PDB entry 6wu8

View 6wu8 on RCSB PDB site
Description: Structure of human SHP2 in complex with inhibitor IACS-13909
Class: hydrolase/hydrolase inhibitor
Keywords: Phosphatase, Inhibitor, Complex, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2020-05-04, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-17, with a file datestamp of 2021-03-12.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6wu8a1, d6wu8a2, d6wu8a3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6wu8b1, d6wu8b2, d6wu8b3
  • Heterogens: U9Y, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wu8A (A:)
gamadimtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthi
kiqntgdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfh
ghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmirc
qelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrels
klaettdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhd
gdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrviv
mttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntert
vwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividi
lidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrie

    Sequence, based on observed residues (ATOM records): (download) 
    >6wu8A (A:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgkea
eklltekgkhgsflvresqshpgdfvlsvrtgddndgkskvthvmircqelkydvggger
fdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlq
qqeckllysrkegqrqenknknryknilpfdhtrvvlhsdyinaniimpkksyiatqgcl
qntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaah
dytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagp
vvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfi
ymavqhyietlqrr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wu8B (B:)
gamadimtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthi
kiqntgdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfh
ghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmirc
qelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrels
klaettdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhd
gdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrviv
mttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntert
vwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividi
lidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrie

    Sequence, based on observed residues (ATOM records): (download) 
    >6wu8B (B:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgkea
eklltekgkhgsflvresqshpgdfvlsvrtgdddgkskvthvmircqelkydvgggerf
dsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsqgfweefetlqqq
eckllysrkegqrqenknknryknilpfdhtrvvlhdgsdyinaniimpefekksyiatq
gclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkes
aahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimd
agpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqy
rfiymavqhyietlqrr