PDB entry 6wrz

View 6wrz on RCSB PDB site
Description: Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.
Class: viral protein
Keywords: Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, nsp16, nsp10, complex, 7-methyl-GpppA, VIRAL PROTEIN
Deposited on 2020-04-30, released 2020-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2'-O-methyltransferase
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (3-300)
      • expression tag (2)
    Domains in SCOPe 2.08: d6wrza1, d6wrza2
  • Chain 'B':
    Compound: non-structural protein 10
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6wrzb_
  • Heterogens: GTA, SAH, ZN, MGP, SO4, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wrzA (A:)
snassqawqpgvampnlykmqrmllekcdlqnygdsatlpkgimmnvakytqlcqylntl
tlavpynmrvihfgagsdkgvapgtavlrqwlptgtllvdsdlndfvsdadstligdcat
vhtankwdliisdmydpktknvtkendskegfftyicgfiqqklalggsvaikitehswn
adlyklmghfawwtafvtnvnassseafligcnylgkpreqidgyvmhanyifwrntnpi
qlssyslfdmskfplklrgtavmslkegqindmilsllskgrliirennrvvissdvlvn
n

    Sequence, based on observed residues (ATOM records): (download) 
    >6wrzA (A:)
assqawqpgvampnlykmqrmllekcdlqnygdsatlpkgimmnvakytqlcqylntltl
avpynmrvihfgagsdkgvapgtavlrqwlptgtllvdsdlndfvsdadstligdcatvh
tankwdliisdmydpktknvtkendskegfftyicgfiqqklalggsvaikitehswnad
lyklmghfawwtafvtnvnassseafligcnylgkpreqidgyvmhanyifwrntnpiql
ssyslfdmskfplklrgtavmslkegqindmilsllskgrliirennrvvissdvlvnn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wrzB (B:)
snaagnatevpanstvlsfcafavdaakaykdylasggqpitncvkmlcthtgtgqaitv
tpeanmdqesfggascclycrchidhpnpkgfcdlkgkyvqipttcandpvgftlkntvc
tvcgmwkgygcscdqlrepmlq

    Sequence, based on observed residues (ATOM records): (download) 
    >6wrzB (B:)
stvlsfcvdaakaykdylasggqpitncvkmlcthtgtgqaitvtpeanmdqesfggasc
clycrchidhpnpkgfcdlkgkyvqipttcandpvgftlkntvctvcgmwkgygcscd