PDB entry 6wrw

View 6wrw on RCSB PDB site
Description: crystal structure of computationally designed protein 2ds25.5 in complex with the human transferrin receptor ectodomain
Deposited on 2020-04-30, released 2021-04-28
The last revision was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transferrin receptor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TFRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02786 (0-End)
      • conflict (21)
  • Chain 'B':
    Compound: Transferrin receptor protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TFRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02786 (0-639)
      • conflict (21)
  • Chain 'C':
    Compound: Computationally designed protein 2DS25.5
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WRW (0-87)
  • Chain 'D':
    Compound: Computationally designed protein 2DS25.5
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WRW (0-87)
  • Heterogens: BMA, CA, MAN, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wrwA (A:)
rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
qnngafnetlfrnqlalatwtiqgaanalsgdvwdidnef

    Sequence, based on observed residues (ATOM records):
    >6wrwA (A:)
rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
qnngafnetlfrnqlalatwtiqgaanalsgdvwdidne

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6wrwB (B:)
rlywddlkrklsekldstdftstikllnensyvpreagsqkdenlalyvenqfrefklsk
vwrdqhfvkiqvkdsaqnsviivdkngrlvylvenpggyvayskaatvtgklvhanfgtk
kdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqtkfpivnaelsffgh
ahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklfgnmegdcpsdwktd
stcrmvtsesknvkltvsnvlkeikilnifgvikgfvepdhyvvvgaqrdawgpgaaksg
vgtalllklaqmfsdmvlkdgfqpsrsiifaswsagdfgsvgatewlegylsslhlkaft
yinldkavlgtsnfkvsaspllytliektmqnvkhpvtgqflyqdsnwaskvekltldna
afpflaysgipavsfcfcedtdypylgttmdtykelieripelnkvaraaaevagqfvik
lthdvelnldyerynsqllsfvrdlnqyradikemglslqwlysargdffratsrlttdf
gnaektdrfvmkklndrvmrveyhflspyvspkespfrhvfwgsgshtlpallenlklrk
qnngafnetlfrnqlalatwtiqgaanalsgdvwdidnef

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6wrwC (C:)
deeeiqkaieellrkgvseeeaaiiivqrfnvavvvvvqderqgkhiseyirryipeadv
ilfanlvvikvethelstrvweaaqkay

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6wrwD (D:)
deeeiqkaieellrkgvseeeaaiiivqrfnvavvvvvqderqgkhiseyirryipeadv
ilfanlvvikvethelstrvweaaqkay