PDB entry 6wo5

View 6wo5 on RCSB PDB site
Description: Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 1a bound to neutralizing antibody 212.1.1 and non neutralizing antibody E1
Class: IMMUNE SYSTEM/Viral Protein
Keywords: HCV, broadly neutralizing antibodies, bNAbs, E2 core, IGHV1-69, IMMUNE SYSTEM, IMMUNE SYSTEM-Viral Protein complex
Deposited on 2020-04-24, released 2020-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fab E1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5
    Domains in SCOPe 2.08: d6wo5a_
  • Chain 'B':
    Compound: Fab E1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (0-220)
    Domains in SCOPe 2.08: d6wo5b1, d6wo5b2
  • Chain 'C':
    Compound: Fab E1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5
    Domains in SCOPe 2.08: d6wo5c_
  • Chain 'D':
    Compound: Fab E1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (0-End)
    Domains in SCOPe 2.08: d6wo5d1, d6wo5d2
  • Chain 'E':
    Compound: Envelope glycoprotein E2
    Species: Hepatitis C virus (isolate H) [TaxId:11108]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (Start-190)
  • Chain 'F':
    Compound: Envelope glycoprotein E2
    Species: Hepatitis C virus (isolate H) [TaxId:11108]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (Start-190)
  • Chain 'G':
    Compound: Fab 212.1.1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (0-End)
    Domains in SCOPe 2.08: d6wo5g_
  • Chain 'H':
    Compound: Fab 212.1.1 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5
    Domains in SCOPe 2.08: d6wo5h_
  • Chain 'I':
    Compound: Fab 212.1.1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (0-End)
    Domains in SCOPe 2.08: d6wo5i1, d6wo5i2
  • Chain 'L':
    Compound: Fab 212.1.1 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WO5 (0-End)
    Domains in SCOPe 2.08: d6wo5l1, d6wo5l2
  • Heterogens: NAG, BMA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wo5A (A:)
evqlleqsgaelkkpgssvkvsckpsdgtfraytlswvrqapgqtlewmgrimptvgitn
yaqkfqgrvtisadmstataymelsslrsddtaiyycakgpyvglgegfsewgqgtlvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgs

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5A (A:)
lleqsgaelkkpgssvkvsckpsdgtfraytlswvrqapgqtlewmgrimptvgitnyaq
kfqgrvtisadmstataymelsslrsddtaiyycakgpyvglgegfsewgqgtlvtvssa
stkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv
tvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6wo5B (B:)
ielelvltqsplslpvtlgqpasiscrstqslvysdgntylnwfhqragqpprrliykvs
nrdsgvperfsgsgsgtdftlkisrveaedvgiyycmqgahwpptfgggtkveinrtvaa
psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdst
yslsstltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6wo5C (C:)
evqlleqsgaelkkpgssvkvsckpsdgtfraytlswvrqapgqtlewmgrimptvgitn
yaqkfqgrvtisadmstataymelsslrsddtaiyycakgpyvglgegfsewgqgtlvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgs

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5C (C:)
lleqsgaelkkpgssvkvsckpsdgtfraytlswvrqapgqtlewmgrimptvgitnyaq
kfqgrvtisadmstataymelsslrsddtaiyycakgpyvglgegfsewgqgtlvtvssa
stkgpsvfplapsssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6wo5D (D:)
ielelvltqsplslpvtlgqpasiscrstqslvysdgntylnwfhqragqpprrliykvs
nrdsgvperfsgsgsgtdftlkisrveaedvgiyycmqgahwpptfgggtkveinrtvaa
psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdst
yslsstltlskadyekhkvyacevthqglsspvtksfnrge

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5D (D:)
ielelvltqsplslpvtlgqpasiscrstqslvysdgntylnwfhqragqpprrliykvs
nrdsgvperfsgsgsgtdftlkisrveaedvgiyycmqgahwpptfgggtkveinrtvaa
psvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdst
yslsstltlskadyekhkvyacevthqglsspvtksfnr

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6wo5G (G:)
qvqlvqsgaevkkpgssvkvsckasggtlssygiswvrqapgqglewlggsipilgtsvy
aqkfqgrvtmtadeststahmelsslrfddtaiyycagvregmaaisgknafdiwgqgtm
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgs

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5G (G:)
qvqlvqsgaevkkpgssvkvsckasggtlssygiswvrqapgqglewlggsipilgtsvy
aqkfqgrvtmtadeststahmelsslrfddtaiyycagvregmaaisgknafdiwgqgtm
vtvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6wo5H (H:)
qvqlvqsgaevkkpgssvkvsckasggtlssygiswvrqapgqglewlggsipilgtsvy
aqkfqgrvtmtadeststahmelsslrfddtaiyycagvregmaaisgknafdiwgqgtm
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscgs

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5H (H:)
vqlvqsgaevkkpgssvkvsckasggtlssygiswvrqapgqglewlggsipilgtsvya
qkfqgrvtmtadeststahmelsslrfddtaiyycagvregmaaisgknafdiwgqgtmv
tvssastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6wo5I (I:)
diqmtqspsslsasvgdrvtitcrasqgisnylawyqqkpgkvpklliyaastlqsgvps
rfsgsgygteftltisslqpedvatyycqqhdnlpltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5I (I:)
diqmtqspsslsasvgdrvtitcrasqgisnylawyqqkpgkvpklliyaastlqsgvps
rfsgsgygteftltisslqpedvatyycqqhdnlpltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6wo5L (L:)
diqmtqspsslsasvgdrvtitcrasqgisnylawyqqkpgkvpklliyaastlqsgvps
rfsgsgygteftltisslqpedvatyycqqhdnlpltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6wo5L (L:)
diqmtqspsslsasvgdrvtitcrasqgisnylawyqqkpgkvpklliyaastlqsgvps
rfsgsgygteftltisslqpedvatyycqqhdnlpltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg