PDB entry 6wml

View 6wml on RCSB PDB site
Description: human tlr8 bound to the potent agonist, gs-9688 (selgantolimod)
Deposited on 2020-04-21, released 2021-02-03
The last revision was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Toll-like receptor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR8, UNQ249/PRO286
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Toll-like receptor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR8, UNQ249/PRO286
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Toll-like receptor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR8, UNQ249/PRO286
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Toll-like receptor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: TLR8, UNQ249/PRO286
    Database cross-references and differences (RAF-indexed):
  • Heterogens: U57, MAN, NAG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wmlA (A:)
rspweenfsrsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnes
fqglqnltkinlnhnpnvqhqngnpgiqsnglnitdgaflnlknlrelllednqlpqips
glpesltelsliqnniynitkegisrlinlknlylawncyfnkvcektniedgvfetltn
lellslsfnslshvppklpsslrklflsntqikyiseedfkglinltlldlsgncprcfn
apfpcvpcdggasinidrfafqnltqlrylnlsstslrkinaawfknmphlkvldlefny
lvgeiasgafltmlprleildlsfnyikgsypqhinisrnfskllslralhlrgyvfqel
reddfqplmqlpnlstinlginfikqidfklfqnfsnleiiylsenrisplvkdtrqsya
nsssfqrhirkrrstdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigpnqfe
nlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasaltelsdlevldls
ynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynleskslvelvfsgnrldi
lwndddnryisifkglknltrldlslnrlkhipneaflnlpasltelhindnmlkffnwt
llqqfprlelldlrgnkllfltdslsdftsslrtlllshnrishlpsgflsevsslkhld
lssnllktinksaletktttklsmlelhgnpfectcdigdfrrwmdehlnvkiprlvdvi
caspgdqrgksivslelttcvsdvteflvpr

    Sequence, based on observed residues (ATOM records):
    >6wmlA (A:)
srsypcdekviaecsnrrlqevpqtvgkyvteldlsdnfithitnesfqglqnltkinln
hnpnvglnitdgaflnlknlrelllednqlpqipsglpesltelsliqnniynitkegis
rlinlknlylawncyfnkvcektniedgvfetltnlellslsfnslshvppklpsslrkl
flsntqikyiseedfkglinltlldlsgncprcfnapfpcvpcdggasinidrfafqnlt
qlrylnlsstslrkinaawfknmphlkvldlefnylvgeiasgafltmlprleildlsfn
yikgsypqhinisrnfskllslralhlrgyvfqelreddfqplmqlpnlstinlginfik
qidfklfqnfsnleiiylsenrisplfefdphsnfyhftrplikpqcaaygkaldlslns
iffigpnqfenlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasalte
lsdlevldlsynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynleskslve
lvfsgnrldilwndddnryisifkglknltrldlslnrlkhipneaflnlpasltelhin
dnmlkffnwtllqqfprlelldlrgnkllfltdsldftsslrtlllshnrishlpsgflv
sslkhldlssnllktinksaletktttklsmlelhgnpfectcdigdfrrwmdehlnvki
prlvdvicaspgdqrgksivsle

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wmlB (B:)
rspweenfsrsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnes
fqglqnltkinlnhnpnvqhqngnpgiqsnglnitdgaflnlknlrelllednqlpqips
glpesltelsliqnniynitkegisrlinlknlylawncyfnkvcektniedgvfetltn
lellslsfnslshvppklpsslrklflsntqikyiseedfkglinltlldlsgncprcfn
apfpcvpcdggasinidrfafqnltqlrylnlsstslrkinaawfknmphlkvldlefny
lvgeiasgafltmlprleildlsfnyikgsypqhinisrnfskllslralhlrgyvfqel
reddfqplmqlpnlstinlginfikqidfklfqnfsnleiiylsenrisplvkdtrqsya
nsssfqrhirkrrstdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigpnqfe
nlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasaltelsdlevldls
ynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynleskslvelvfsgnrldi
lwndddnryisifkglknltrldlslnrlkhipneaflnlpasltelhindnmlkffnwt
llqqfprlelldlrgnkllfltdslsdftsslrtlllshnrishlpsgflsevsslkhld
lssnllktinksaletktttklsmlelhgnpfectcdigdfrrwmdehlnvkiprlvdvi
caspgdqrgksivslelttcvsdvteflvpr

    Sequence, based on observed residues (ATOM records):
    >6wmlB (B:)
srsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnesfqglqnlt
kinlnhnpnvglnitdgaflnlknlrelllednqlpqipsglpesltelsliqnniynit
kegisrlinlknlylawncyfnkvcektniedgvfetltnlellslsfnslshvppklps
slrklflsntqikyiseedfkglinltlldlsgncprcfnapfpcvpcdggasinidrfa
fqnltqlrylnlsstslrkinaawfknmphlkvldlefnylvgeiasgafltmlprleil
dlsfnyikgsypqhinisrnfskllslralhlrgyvfqelreddfqplmqlpnlstinlg
infikqidfklfqnfsnleiiylsenrisplfefdphsnfyhftrplikpqcaaygkald
lslnsiffigpnqfenlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdna
saltelsdlevldlsynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynles
kslvelvfsgnrldilwndddnryisifkglknltrldlslnrlkhipneaflnlpaslt
elhindnmlkffnwtllqqfprlelldlrgnkllfltdslsdftsslrtlllshnrishl
psgflsevsslkhldlssnllktinksaletktttklsmlelhgnpfectcdigdfrrwm
dehlnvkiprlvdvicaspgdqrgksivsle

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wmlC (C:)
rspweenfsrsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnes
fqglqnltkinlnhnpnvqhqngnpgiqsnglnitdgaflnlknlrelllednqlpqips
glpesltelsliqnniynitkegisrlinlknlylawncyfnkvcektniedgvfetltn
lellslsfnslshvppklpsslrklflsntqikyiseedfkglinltlldlsgncprcfn
apfpcvpcdggasinidrfafqnltqlrylnlsstslrkinaawfknmphlkvldlefny
lvgeiasgafltmlprleildlsfnyikgsypqhinisrnfskllslralhlrgyvfqel
reddfqplmqlpnlstinlginfikqidfklfqnfsnleiiylsenrisplvkdtrqsya
nsssfqrhirkrrstdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigpnqfe
nlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasaltelsdlevldls
ynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynleskslvelvfsgnrldi
lwndddnryisifkglknltrldlslnrlkhipneaflnlpasltelhindnmlkffnwt
llqqfprlelldlrgnkllfltdslsdftsslrtlllshnrishlpsgflsevsslkhld
lssnllktinksaletktttklsmlelhgnpfectcdigdfrrwmdehlnvkiprlvdvi
caspgdqrgksivslelttcvsdvteflvpr

    Sequence, based on observed residues (ATOM records):
    >6wmlC (C:)
srsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnesfqglqnlt
kinlnhnpnvglnitdgaflnlknlrelllednqlpqipsglpesltelsliqnniynit
kegisrlinlknlylawncyfnkvcektniedgvfetltnlellslsfnslshvppklps
slrklflsntqikyiseedfkglinltlldlsgncprcfnapfpcvpcdggasinidrfa
fqnltqlrylnlsstslrkinaawfknmphlkvldlefnylvgeiasgafltmlprleil
dlsfnyikgsypqhinisrnfskllslralhlrgyvfqelreddfqplmqlpnlstinlg
infikqidfklfqnfsnleiiylsenrisplfefdphsnfyhftrplikpqcaaygkald
lslnsiffigpnqfenlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdna
saltelsdlevldlsynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynles
kslvelvfsgnrldilwndddnryisifkglknltrldlslnrlkhipneaflnlpaslt
elhindnmlkffnwtllqqfprlelldlrgnkllfltsslrtlllshnrishllkhldls
snlsmlelhgnvkiprlvdvi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6wmlD (D:)
rspweenfsrsypcdekkqndsviaecsnrrlqevpqtvgkyvteldlsdnfithitnes
fqglqnltkinlnhnpnvqhqngnpgiqsnglnitdgaflnlknlrelllednqlpqips
glpesltelsliqnniynitkegisrlinlknlylawncyfnkvcektniedgvfetltn
lellslsfnslshvppklpsslrklflsntqikyiseedfkglinltlldlsgncprcfn
apfpcvpcdggasinidrfafqnltqlrylnlsstslrkinaawfknmphlkvldlefny
lvgeiasgafltmlprleildlsfnyikgsypqhinisrnfskllslralhlrgyvfqel
reddfqplmqlpnlstinlginfikqidfklfqnfsnleiiylsenrisplvkdtrqsya
nsssfqrhirkrrstdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigpnqfe
nlpdiaclnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasaltelsdlevldls
ynshyfriagvthhlefiqnftnlkvlnlshnniytltdkynleskslvelvfsgnrldi
lwndddnryisifkglknltrldlslnrlkhipneaflnlpasltelhindnmlkffnwt
llqqfprlelldlrgnkllfltdslsdftsslrtlllshnrishlpsgflsevsslkhld
lssnllktinksaletktttklsmlelhgnpfectcdigdfrrwmdehlnvkiprlvdvi
caspgdqrgksivslelttcvsdvteflvpr

    Sequence, based on observed residues (ATOM records):
    >6wmlD (D:)
sypcdekiaecsnrrlqevpqtvgkteldlsdnfithitnltkinlnhnpnglnitdgaf
lnlknlrelllednqlpqipsglpesltelsliqnniynitkisrlinlknlylawncyf
nkvcektniedgvfetltnlellslsfnslshvppklpsslrklflsntqikyiseedfk
glinltlldlsgncprcfnapfpcvpcdggasinidrfafqnltqlrylnlsstslrkin
aawfknmphlkvldlefnylvgeiasgafltmlprleildlsfnyikgsypqhinisrnf
skllslralhlrgyvfqelreddfqplmqlpnlstinlginfikqidfklfqnfsnleii
ylsenrisplfefdphsnfyhftrplikpqcaaygkaldlslnsiffigpnqfenlpdia
clnlsansnaqvlsgtefsaiphvkyldltnnrldfdnasaltelsdlevldlsynshyf
riagvthhlefiqnftnlkvlnlshnniytltdkynleskslvelvfsgnrldilwnddd
nryisifkglknltrldlslnrlkhipneaflnlpasltelhindnmlkffnwtllqqfp
rlelldlrgnkllfltdslsdftsslrtlllshnrishlpsvsslkhldlssnllktink
saklsmlelhgnpfectcdigdfrrlnvkiprlvdvicaspqrgksiv