PDB entry 6wl6

View 6wl6 on RCSB PDB site
Description: Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE
Class: transferase/inhibitor
Keywords: Deoxyhypusine, Inhibitor, Transferase, TRANSFERASE-INHIBITOR complex
Deposited on 2020-04-18, released 2020-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6wl6a_
  • Chain 'B':
    Compound: deoxyhypusine synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHPS, DS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6wl6b_
  • Heterogens: 91A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wl6A (A:)
ggsmegslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqat
nfgravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretir
ylvqhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyc
kfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspalt
dgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmr
ngadyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaq
kmdafmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >6wl6A (A:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqrrpl
tsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefgin
rignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywa
qknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilggg
vvkgadyavyintaqefdgsqpvkvyadaslvfpllvaetfaqkmdafm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wl6B (B:)
ggsmegslereapagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqat
nfgravqqvnamiekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretir
ylvqhnmvdvlvttaggveedlikclaptylgefslrgkelrenginrignllvpnenyc
kfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspalt
dgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmr
ngadyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaq
kmdafmhekned

    Sequence, based on observed residues (ATOM records): (download) 
    >6wl6B (B:)
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplshadltqsrr
pltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefl
renginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpe
svyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifakctgm
iilgggvvkgadyavyintaqefdgqpvkvyadaslvfpllvaetfaqkmdaf