PDB entry 6wi9

View 6wi9 on RCSB PDB site
Description: human secretin receptor gs complex
Deposited on 2020-04-09, released 2020-08-12
The last revision was dated 2020-09-02, with a file datestamp of 2020-08-28.
Experiment type: EM
Resolution: 4.3 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63092 (Start-393)
      • conflict (225)
      • conflict (267)
      • conflict (270)
      • conflict (273)
      • conflict (279)
      • conflict (283-284)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Nanobody35
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WI9 (0-End)
  • Chain 'P':
    Compound: Secretin
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Secretin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: SCTR
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wi9A (A:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkntivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqadyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvgaqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqaalklfdsiwnnkwlrdtsvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records):
    >6wi9A (A:)
qrneekaqreankkiekqlqkdkqvyrathrllllgsgifetkfqvdkvnfhmfdvgaqr
derrkwiqcfndvtaiifvvanrlqaalklfdsiwnnkwlrdtsvilflnkqdiedyfpe
faryttpedatpepgedprvtrakyfirdeflristasgdgrhycyphftnirrvfndcr
diiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wi9B (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6wi9B (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6wi9G (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6wi9G (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6wi9N (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >6wi9N (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtv

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >6wi9P (P:)
hsdgtftselsrlregarlqrllqglv

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6wi9R (R:)
dykddddlevlfqgpahstgalprlcdvlqvlweeqdqclqelsreqtgdlgteqpvpgc
egmwdniscwpssvpgrmvevecprflrmltsrngslfrnctqdgwsetfprpnlacgvn
vndssnekrhsyllklkvmytvgyssslvmllvalgilcafrrlhctrnyihmhlfvsfi
lralsnfikdavlfssddvtycdahragcklvmvlfqycimanyswllveglylhtllai
sffserkylqgfvafgwgspaifvalwaiarhfledvgcwdinanasiwwiirgpvilsi
linfilfinilrilmrklrtqetrgnevshykrlarstllliplfgihyivfafspedam
eiqlffelalgsfqglvvavlycflngevqlevqkkwqqwhlrefplhpvasfsnstkas
hleqsqgtcrtsiipaglevlfqgphhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6wi9R (R:)
rlcdvlqvlweeqdqclqelsreqtgdlgteqpvpgcegmwdniscwpssvpgrmvevec
prflrmltsrngslfrnctqdgwsetfprpnlacgvnvndssnekrhsyllklkvmytvg
yssslvmllvalgilcafrrlhctrnyihmhlfvsfilralsnfikdavlfragcklvmv
lfqycimanyswllveglylhtllaisffserkylqgfvafgwgspaifvalwaiarhfl
edvgcwdinanasiwwiirgpvilsilinfilfinilrilmrklrtqetrgnevshykrl
arstllliplfgihyivfafspedameiqlffelalgsfqglvvavlycflngevqlevq
kkwqqwhl