PDB entry 6whx

View 6whx on RCSB PDB site
Description: glun1b-glun2b nmda receptor in complex with glun2b antagonist sdz 220- 040, class 2
Deposited on 2020-04-08, released 2020-07-15
The last revision was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: EM
Resolution: 4.09 Å
R-factor: N/A
AEROSPACI score: 0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ionotropic glutamate receptor , NMDA receptor GluN1b
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHX
  • Chain 'B':
    Compound: Ionotropic glutamate receptor , NMDA receptor GluN2B
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHX
  • Chain 'C':
    Compound: Ionotropic glutamate receptor , NMDA receptor GluN1b
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHX
  • Chain 'D':
    Compound: Ionotropic glutamate receptor , NMDA receptor GluN2B
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHX
  • Heterogens: QGP, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6whxA (A:)
mstmhlltfallfscsfaraasdpkivnigavlstrkheqmfreavnqankrhgswkiql
qatsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvynwnhiillvsddhegraaqkrl
etlleereskskkrnyenldqlsydnkrgpkaekvlqfdpgtknvtallmearelearvi
ilsaseddaatvyraaamldmtgsgyvwlvgereisgnalryapdgiiglqlingknesa
hisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrvlmsskyadgvtgrve
fnedgdrkfaqysimnlqnrklvqvgiyngthvipndrkiiwpggetekprgyqmstrlk
ivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtspgsprhtvpqccygfc
idlliklartmqftyevhlvadgkfgtqervqnsnkkewngmmgellsgqadmivaplti
nneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwllvglsvhvvavmlyl
ldrfspfgrfkvnsqsestdaltlssamwfswgvllnsgigegaprsfsarilgmvwagf
amiivasytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvel
stmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfg
igmrkdspwkqqvslsilkshengfmedldktwvryqecdsrsnapatltcenmagvfml
vaggivagiflifieiaykrhkdarrkqmqlafaavnvwrknlqdrksgraepdpkkkat
fraitstlassfkrrrsskdtstgggrgalqnqkdtvlprraiereegqlqlcsrhres

    Sequence, based on observed residues (ATOM records):
    >6whxA (A:)
kivnigavlstrkheqmfreavnqankriqlqatsvthkpnaiqmalsvcedlissqvya
ilvshtptpvsytagfyripvlglttrmsiysdksihlsflrtvppyshqssvwfemmrv
ynwnhiillvsddhegraaqkrletlleereskrgpkaekvlqfdpgtknvtallmeare
learviilsaseddaatvyraaamldmtgsgyvwlvgereisgnalryapdgiiglqlin
gknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrvlmsskyadg
vtgrvefnedgdrkfaqysimnlqnrklvqvgiyngthvipndrkiiwpggetekprgyq
mstrlkivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtspgsprhtvpq
ccygfcidlliklartmqftyevhlvadgkfgtqervqnsnkkewngmmgellsgqadmi
vapltinneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwllvglsvhvv
avmlylldrfstlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivasytan
laaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhn
yesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkq
qvslsilkshengfmedldktwvryqecdsrsnapatltcenmagvfmlvaggivagifl
ifieiaykrhk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6whxB (B:)
mgtmrlfllavlflfsfaratgwshpqfekgggsgggsggsawshpqfekgalvprgrsq
ksppsigiavilvgtsdevaikdahekddfhhlsvvprvelvamnetdpksiitricdlm
sdrkiqgvvfaddtdqeaiaqildfisaqtltpilgihggssmimadkdessmffqfgps
ieqqasvmlnimeeydwyifsivttyfpgyqdfvnkirstiensfvgweleevllldmsl
ddgdskiqnqlkklqspiillyctkeeatyifevansvgltgygytwivpslvagdtdtv
psefptglisvsydewdyglparvrdgiaiittaasdmlsehsfipepksscynthekri
yqsnmlnrylinvtfegrdlsfsedgyqmhpklviillnkerkwervgkwkdkslqmkyy
vwprmcpeteeqeddhlsivtleeapfvivesvdplsgtcmrntvpcqkriisenktdee
pgyikkcckgfcidilkkisksvkftydlylvtngkhgkkingtwngmigevvmkrayma
vgsltineersevvdfsvpfietgisvmvsrsngtvspsaflepfsacvwvmmfvmlliv
savavfvfeyfspvgynrsladgrepggpsftigkaiwllwglvfnnsvpvqnpkgttsk
imvsvwaffaviflasytanlaafmiqeeyvdqvsglsdkkfqrpndfsppfrfgtvpng
sternirnnyaemhaymgkfnqrgvddallslktgkldafiydaavlnymagrdegcklv
tigsgkvfastgygiaiqkdsgwkrqvdlailqlfgdgemeelealwltgichneknevm
ssqldidnmagvfymlgaamalslitfisehlfywqfrhsfmg

    Sequence, based on observed residues (ATOM records):
    >6whxB (B:)
sigiavilvgtsdevaikdahekddfhhlsvvprvelvamnetdpksiitricdlmsdrk
iqgvvfaddtdqeaiaqildfisaqtltpilgihggssmimadkdessmffqfgpsieqq
asvmlnimeeydwyifsivttyfpgyqdfvnkirstiensfvgweleevllldmslddgd
skiqnqlkklqspiillyctkeeatyifevansvgltgygytwivpslvagdtdtvpsef
ptglisvsydewdyglparvrdgiaiittaasdmlsehsfipepksscynthekriyqsn
mlnrylinvtfegrdlsfsedgyqmhpklviillnkerkwervgkwkdkslqmkyyvwpr
mddhlsivtleeapfvivesvdplsgtcmrntvpcqkriisenktdeepgyikkcckgfc
idilkkisksvkftydlylvtngkhgkkingtwngmigevvmkraymavgsltineerse
vvdfsvpfietgisvmvsrsngtvspsaflepfsacvwvmmfvmllivsavavfvfeyft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeeyvd
qvsglsdkkfqrpndfsppfrfgtvpngsternirnnyaemhaymgkfnqrgvddallsl
ktgkldafiydaavlnymagrdegcklvtigsgkvfastgygiaiqkdsgwkrqvdlail
qlfgdgemeelealwltgichneknevmssqldidnmagvfymlgaamalslitfisehl
fywq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6whxC (C:)
mstmhlltfallfscsfaraasdpkivnigavlstrkheqmfreavnqankrhgswkiql
qatsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvynwnhiillvsddhegraaqkrl
etlleereskskkrnyenldqlsydnkrgpkaekvlqfdpgtknvtallmearelearvi
ilsaseddaatvyraaamldmtgsgyvwlvgereisgnalryapdgiiglqlingknesa
hisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrvlmsskyadgvtgrve
fnedgdrkfaqysimnlqnrklvqvgiyngthvipndrkiiwpggetekprgyqmstrlk
ivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtspgsprhtvpqccygfc
idlliklartmqftyevhlvadgkfgtqervqnsnkkewngmmgellsgqadmivaplti
nneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwllvglsvhvvavmlyl
ldrfspfgrfkvnsqsestdaltlssamwfswgvllnsgigegaprsfsarilgmvwagf
amiivasytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvel
stmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfg
igmrkdspwkqqvslsilkshengfmedldktwvryqecdsrsnapatltcenmagvfml
vaggivagiflifieiaykrhkdarrkqmqlafaavnvwrknlqdrksgraepdpkkkat
fraitstlassfkrrrsskdtstgggrgalqnqkdtvlprraiereegqlqlcsrhres

    Sequence, based on observed residues (ATOM records):
    >6whxC (C:)
kivnigavlstrkheqmfreavnqankriqlqatsvthkpnaiqmalsvcedlissqvya
ilvshtptpvsytagfyripvlglttrmsiysdksihlsflrtvppyshqssvwfemmrv
ynwnhiillvsddhegraaqkrletlleereskydnkrgpkaekvlqfdpgtknvtallm
earelearviilsaseddaatvyraaamldmtgsgyvwlvgereisgnalryapdgiigl
qlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrvlmssk
yadgvtgrvefnedgdrkfaqysimnlqnrklvqvgiyngthvipndrkiiwpggetekp
rgyqmstrlkivtihqepfvyvkptmsdgtckeeftvngdpvkkvictgpndtspgsprh
tvpqccygfcidlliklartmqftyevhlvadgkfgtqervqnsnkkewngmmgellsgq
admivapltinneraqyiefskpfkyqgltilvkkeiprstldsfmqpfqstlwllvgls
vhvvavmlylldrfstlssamwfswgvllnsgigegaprsfsarilgmvwagfamiivas
ytanlaaflvldrpeeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhm
ekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkds
pwkqqvslsilkshengfmedldktwvryqecdsrsnapatltcenmagvfmlvaggiva
giflifieiaykrhk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6whxD (D:)
mgtmrlfllavlflfsfaratgwshpqfekgggsgggsggsawshpqfekgalvprgrsq
ksppsigiavilvgtsdevaikdahekddfhhlsvvprvelvamnetdpksiitricdlm
sdrkiqgvvfaddtdqeaiaqildfisaqtltpilgihggssmimadkdessmffqfgps
ieqqasvmlnimeeydwyifsivttyfpgyqdfvnkirstiensfvgweleevllldmsl
ddgdskiqnqlkklqspiillyctkeeatyifevansvgltgygytwivpslvagdtdtv
psefptglisvsydewdyglparvrdgiaiittaasdmlsehsfipepksscynthekri
yqsnmlnrylinvtfegrdlsfsedgyqmhpklviillnkerkwervgkwkdkslqmkyy
vwprmcpeteeqeddhlsivtleeapfvivesvdplsgtcmrntvpcqkriisenktdee
pgyikkcckgfcidilkkisksvkftydlylvtngkhgkkingtwngmigevvmkrayma
vgsltineersevvdfsvpfietgisvmvsrsngtvspsaflepfsacvwvmmfvmlliv
savavfvfeyfspvgynrsladgrepggpsftigkaiwllwglvfnnsvpvqnpkgttsk
imvsvwaffaviflasytanlaafmiqeeyvdqvsglsdkkfqrpndfsppfrfgtvpng
sternirnnyaemhaymgkfnqrgvddallslktgkldafiydaavlnymagrdegcklv
tigsgkvfastgygiaiqkdsgwkrqvdlailqlfgdgemeelealwltgichneknevm
ssqldidnmagvfymlgaamalslitfisehlfywqfrhsfmg

    Sequence, based on observed residues (ATOM records):
    >6whxD (D:)
sigiavilvgtsdevaikdahekddfhhlsvvprvelvamnetdpksiitricdlmsdrk
iqgvvfaddtdqeaiaqildfisaqtltpilgihggssmimadkdessmffqfgpsieqq
asvmlnimeeydwyifsivttyfpgyqdfvnkirstiensfvgweleevllldmslddgd
skiqnqlkklqspiillyctkeeatyifevansvgltgygytwivpslvagdtdtvpsef
ptglisvsydewdyglparvrdgiaiittaasdmlsehsfipepksscynthekriyqsn
mlnrylinvtfegrdlsfsedgyqmhpklviillnkerkwervgkwkdkslqmkyyvwpr
mddhlsivtleeapfvivesvdplsgtcmrntvpcqkriisenktdeepgyikkcckgfc
idilkkisksvkftydlylvtngkhgkkingtwngmigevvmkraymavgsltineerse
vvdfsvpfietgisvmvsrsngtvspsaflepfsacvwvmmfvmllivsavavfvfeyft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqeeyvd
qvsglsdkkfqrpndfsppfrfgtvpngsternirnnyaemhaymgkfnqrgvddallsl
ktgkldafiydaavlnymagrdegcklvtigsgkvfastgygiaiqkdsgwkrqvdlail
qlfgdgemeelealwltgichneknevmssqldidnmagvfymlgaamalslitfisehl
fywq