PDB entry 6wha

View 6wha on RCSB PDB site
Description: htr2a bound to 25-cn-nboh in complex with a mini-galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scfv16) obtained by cryo-electron microscopy (cryoem)
Deposited on 2020-04-07, released 2020-09-23
The last revision was dated 2020-09-23, with a file datestamp of 2020-09-18.
Experiment type: EM
Resolution: 3.36 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble cytochrome b562,5-hydroxytryptamine receptor 2A chimera
    Species: Homo sapiens [TaxId:9606]
    Gene: HTR2A, HTR2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: G subunit q (Gi2-mini-Gq chimeric)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHA (Start-245)
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: single Fab chain (svFv16)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WHA
  • Heterogens: U0G

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6whaA (A:)
mktiialsyifclvfadykddddaklqtmhhhhhhhhhhenlyfqggttmadlednwetl
ndnlkviekadnaaqvkdaltkmraaaldaqkatppkledkspdspemkdfrhgfdilvg
qiddalklanegkvkeaqaaaeqlkttrnayiqkylgslsllhlqeknwsalltavviil
tiagnilvimavslekklqnatnyflmslaiadmllgflvmpvsmltilygyrwplpskl
cavwiyldvlfstasimhlcaisldryvaiqnpihhsrfnsrtkaflkiiavwtisvgis
mpipvfglqddskvfkegsclladdnfvligsfvsffipltimvityfltikslqkeatl
cvsdlgtraklasfsflpqsslsseklfqrsihrepgsytgrrtmqsisneqkackvlgi
vfflfvvmwcpffitnimavickescnedvigallnvfvwigylssavnplvytlfnkty
rsafsryiqcqykenkk

    Sequence, based on observed residues (ATOM records):
    >6whaA (A:)
viiltiagnilvimavlqnatnyflmslaiadmllgflvmpvsmltilygyrwpsklcav
wiyldvlfstasimhlcaisldryvaiqnpihhsrfnsrtkaflkiiavwtisvgismpi
pvfglqddskvfkgsclladdnfvligsfvsffipltimvityfltikslqisneqkack
vlgivfflfvvmwcpffitnimavnedvigallnvfvwigylssavnplvytlfnktyrs
afsr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6whaB (B:)
mgstvsaedkaaaerskmidknlredgekarrtlrllllgadnsgkstivkqmrilhggs
ggsggtsgifetkfqvdkvnfhmfdvggqrderrkwiqcfndvtaiifvvdssdynrlqe
alndfksiwnnrwlrtisvilflnkqdllaekvlagkskiedyfpefaryttpedatpep
gedprvtrakyfirkefvdistasgdgrhicyphftcavdtenarrifndckdiilqmnl
reynlv

    Sequence, based on observed residues (ATOM records):
    >6whaB (B:)
vsaedkaaaerskmidknlredgekarrtlrllllgadnsgkstivkgifetkfqvdkvn
fhmfdvgrrkwiqcfndvtaiifvvdssdynrlqealndfksiwnnrwlrtisvilflnk
qdllaekvlagkskiedyfpefaryttpdprvtrakyfirkefvdistasgdgrhicyph
ftcvdtenarrifndckdiilqmnlreynlv

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6whaC (C:)
mhhhhhhlevlfqgpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgr
iqmrtrrtlrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmt
cayapsgnyvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssg
dttcalwdietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtf
tghesdinaicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksg
rlllagyddfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >6whaC (C:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6whaD (D:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >6whaD (D:)
qarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpf

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6whaE (E:)
dvqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyy
adtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvs
sggggsggggsggggsdivmtqatssvpvtpgesvsiscrssksllhsngntylywflqr
pgqspqlliyrmsnlasgvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfg
agtklelkaaalevlfqgphhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6whaE (E:)
vqlvesggglvqpggsrklscsasgfafssfgmhwvrqapekglewvayissgsgtiyya
dtvkgrftisrddpkntlflqmtslrsedtamyycvrsiyyygsspfdfwgqgttltvss
divmtqatssvpvpgesvsiscrssksllhsngntylywflqrpgqspqlliyrmsnlas
gvpdrfsgsgsgtaftltisrleaedvgvyycmqhleypltfgagtklel