PDB entry 6weq

View 6weq on RCSB PDB site
Description: denv1 ns1 in complex with neutralizing 2b7 fab fragment
Deposited on 2020-04-02, released 2020-12-23
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-structural protein 1
    Species: Dengue virus 1 [TaxId:11053]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9J7C6 (23-End)
      • expression tag (13-22)
  • Chain 'B':
    Compound: Non-structural protein 1
    Species: Dengue virus 1 [TaxId:11053]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9J7C6 (23-End)
      • expression tag (13-22)
  • Chain 'C':
    Compound: Non-structural protein 1
    Species: Dengue virus 1 [TaxId:11053]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9J7C6 (23-End)
      • expression tag (13-22)
  • Chain 'D':
    Compound: Non-structural protein 1
    Species: Dengue virus 1 [TaxId:11053]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9J7C6 (23-End)
      • expression tag (13-22)
  • Chain 'E':
    Compound: 2B7 Fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'F':
    Compound: 2B7 Fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'G':
    Compound: 2B7 Fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'H':
    Compound: 2B7 Fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'I':
    Compound: 2B7 Fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'J':
    Compound: 2B7 Fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'K':
    Compound: 2B7 Fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Chain 'L':
    Compound: 2B7 Fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WEQ
  • Heterogens: NAG, SO4

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6weqA (A:)
ahhhhhhssgvdlgtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqa
dspkrlsaaigkaweegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgi
laqgkkmirpqpmehkyswkswgkakiigadvqnttfiidgpntpecpdnqrawniweve
dygfgifttniwlklrdsytqvcdhrlmsaaikdskavhadmgywieseknetwklaras
fievktciwpkshtlwsngvlesemiipkiyggpisqhnyrpgyftqtagpwhlgkleld
fdfcegttvvvdehcgnrgpslrtttvtgkiihewccrsctlpplrfkgedgcwygmeir
pvkdkeenlvksmvsa

    Sequence, based on observed residues (ATOM records):
    >6weqA (A:)
gtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqadspkrlsaaigka
weegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgilaqgkkmirpqpq
nttfiidgpntpecpdnqrawniwevedygfgifttniwlklrdsytqvcdhrlmsaaik
dskavhadmgywieseknetwklarasfievktciwpkshtlwsngvlesemiipkiygg
pisqhnyrpgyftqtagpwhlgkleldfdfcegttvvvdehcgnrgpslrtttvtgkiih
ewccrsctlpplrfkgedgcwygmeirpvkdkeenlvksm

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6weqB (B:)
ahhhhhhssgvdlgtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqa
dspkrlsaaigkaweegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgi
laqgkkmirpqpmehkyswkswgkakiigadvqnttfiidgpntpecpdnqrawniweve
dygfgifttniwlklrdsytqvcdhrlmsaaikdskavhadmgywieseknetwklaras
fievktciwpkshtlwsngvlesemiipkiyggpisqhnyrpgyftqtagpwhlgkleld
fdfcegttvvvdehcgnrgpslrtttvtgkiihewccrsctlpplrfkgedgcwygmeir
pvkdkeenlvksmvsa

    Sequence, based on observed residues (ATOM records):
    >6weqB (B:)
gtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqadspkrlsaaigka
weegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgilaqgkkmirpqpq
nttfiidgpntpecpdnqrawniwevedygfgifttniwlklrdsytqvcdhrlmsaaik
dskavhadmgywieseknetwklarasfievktciwpkshtlwsngvlesemiipkiygg
pisqhnyrpgyftqtagpwhlgkleldfdfcegttvvvdehcgnrgpslrtttvtgkiih
ewccrsctlpplrfkgedgcwygmeirpvkdkeenlvksm

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6weqC (C:)
ahhhhhhssgvdlgtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqa
dspkrlsaaigkaweegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgi
laqgkkmirpqpmehkyswkswgkakiigadvqnttfiidgpntpecpdnqrawniweve
dygfgifttniwlklrdsytqvcdhrlmsaaikdskavhadmgywieseknetwklaras
fievktciwpkshtlwsngvlesemiipkiyggpisqhnyrpgyftqtagpwhlgkleld
fdfcegttvvvdehcgnrgpslrtttvtgkiihewccrsctlpplrfkgedgcwygmeir
pvkdkeenlvksmvsa

    Sequence, based on observed residues (ATOM records):
    >6weqC (C:)
gtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqadspkrlsaaigka
weegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgilaqgkkmirpqpq
nttfiidgpntpecpdnqrawniwevedygfgifttniwlklrdsytqvcdhrlmsaaik
dskavhadmgywieseknetwklarasfievktciwpkshtlwsngvlesemiipkiygg
pisqhnyrpgyftqtagpwhlgkleldfdfcegttvvvdehcgnrgpslrtttvtgkiih
ewccrsctlpplrfkgedgcwygmeirpvkdkeenlvksm

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6weqD (D:)
ahhhhhhssgvdlgtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqa
dspkrlsaaigkaweegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgi
laqgkkmirpqpmehkyswkswgkakiigadvqnttfiidgpntpecpdnqrawniweve
dygfgifttniwlklrdsytqvcdhrlmsaaikdskavhadmgywieseknetwklaras
fievktciwpkshtlwsngvlesemiipkiyggpisqhnyrpgyftqtagpwhlgkleld
fdfcegttvvvdehcgnrgpslrtttvtgkiihewccrsctlpplrfkgedgcwygmeir
pvkdkeenlvksmvsa

    Sequence, based on observed residues (ATOM records):
    >6weqD (D:)
gtenlyfqsnadsgcvinwkgrelkcgsgifvtnevhtwteqykfqadspkrlsaaigka
weegvcgirsatrlenimwkqisnelnhillendmkftvvvgdvsgilaqgkkmirpqpq
nttfiidgpntpecpdnqrawniwevedygfgifttniwlklrdsytqvcdhrlmsaaik
dskavhadmgywieseknetwklarasfievktciwpkshtlwsngvlesemiipkiygg
pisqhnyrpgyftqtagpwhlgkleldfdfcegttvvvdehcgnrgpslrtttvtgkiih
ewccrsctlpplrfkgedgcwygmeirpvkdkeenlvksm

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6weqE (E:)
mewswiflfllsgtagvhsevqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkp
gqdlewigyinpyndmtkysenfkgkatltsdkssstafmelssltsedsavyycargyl
lrtgcfdywgqgttltvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtw
nsgslsssvhtfpallqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkklepsg
pistinpcppckechkcpapnleggpsv

    Sequence, based on observed residues (ATOM records):
    >6weqE (E:)
vqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkpgqdlewigyinpyndmtkys
enfkgkatltsdkssstafmelssltsedsavyycargyllrtgcfdywgqgttltvssa
kttppsvyplapgdttgssvtlgclvkgyfpesvtvtwnsgssvhtfpallqsglytmss
svtvpsstwpsqtvtcsvahpassttvdkkleps

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6weqF (F:)
metdtlllwvlllwvpgstgnivltqspaslavslgqratiscrasesvdsygysfmhwy
qqkpgqppkvliylasnlesgvparfsgsgsrtdftltidpveaddaatyycqqnnenpl
tfgagtklelkradaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserq
ngvlnswtdqdskdstysmsstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6weqF (F:)
nivltqspaslavslgqratiscrasesvdsygysfmhwyqqkpgqppkvliylasnles
gvparfsgsgsrtdftltidpveaddaatyycqqnnenpltfgagtklelkradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnr

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6weqG (G:)
mewswiflfllsgtagvhsevqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkp
gqdlewigyinpyndmtkysenfkgkatltsdkssstafmelssltsedsavyycargyl
lrtgcfdywgqgttltvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtw
nsgslsssvhtfpallqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkklepsg
pistinpcppckechkcpapnleggpsv

    Sequence, based on observed residues (ATOM records):
    >6weqG (G:)
vqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkpgqdlewigyinpyndmtkys
enfkgkatltsdkssstafmelssltsedsavyycargyllrtgcfdywgqgttltvssa
kttppsvyplapdttgssvtlgclvkgyfpesvtvtwnsgssvhtfpallqsglytmsss
vtvpsstwpsqtvtcsvahpassttvdkkleps

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6weqH (H:)
metdtlllwvlllwvpgstgnivltqspaslavslgqratiscrasesvdsygysfmhwy
qqkpgqppkvliylasnlesgvparfsgsgsrtdftltidpveaddaatyycqqnnenpl
tfgagtklelkradaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserq
ngvlnswtdqdskdstysmsstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6weqH (H:)
nivltqspaslavslgqratiscrasesvdsygysfmhwyqqkpgqppkvliylasnles
gvparfsgsgsrtdftltidpveaddaatyycqqnnenpltfgagtklelkradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnr

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6weqI (I:)
mewswiflfllsgtagvhsevqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkp
gqdlewigyinpyndmtkysenfkgkatltsdkssstafmelssltsedsavyycargyl
lrtgcfdywgqgttltvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtw
nsgslsssvhtfpallqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkklepsg
pistinpcppckechkcpapnleggpsv

    Sequence, based on observed residues (ATOM records):
    >6weqI (I:)
vqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkpgqdlewigyinpyndmtkys
enfkgkatltsdkssstafmelssltsedsavyycargyllrtgcfdywgqgttltvssa
kttppsvyplapdttgssvtlgclvkgyfpesvtvtwnsgssvhtfpallqsglytmsss
vtvpsstwpsqtvtcsvahpassttvdkkleps

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6weqJ (J:)
metdtlllwvlllwvpgstgnivltqspaslavslgqratiscrasesvdsygysfmhwy
qqkpgqppkvliylasnlesgvparfsgsgsrtdftltidpveaddaatyycqqnnenpl
tfgagtklelkradaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserq
ngvlnswtdqdskdstysmsstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6weqJ (J:)
nivltqspaslavslgqratiscrasesvdsygysfmhwyqqkpgqppkvliylasnles
gvparfsgsgsrtdftltidpveaddaatyycqqnnenpltfgagtklelkradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnr

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6weqK (K:)
mewswiflfllsgtagvhsevqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkp
gqdlewigyinpyndmtkysenfkgkatltsdkssstafmelssltsedsavyycargyl
lrtgcfdywgqgttltvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtw
nsgslsssvhtfpallqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkklepsg
pistinpcppckechkcpapnleggpsv

    Sequence, based on observed residues (ATOM records):
    >6weqK (K:)
vqlqqsgpelvkpgasvkmsckasgctltncfmhwmkqkpgqdlewigyinpyndmtkys
enfkgkatltsdkssstafmelssltsedsavyycargyllrtgcfdywgqgttltvssa
kttppsvyplapdttgssvtlgclvkgyfpesvtvtwnsgssvhtfpallqsglytmsss
vtvpsstwpsqtvtcsvahpassttvdkkleps

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6weqL (L:)
metdtlllwvlllwvpgstgnivltqspaslavslgqratiscrasesvdsygysfmhwy
qqkpgqppkvliylasnlesgvparfsgsgsrtdftltidpveaddaatyycqqnnenpl
tfgagtklelkradaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserq
ngvlnswtdqdskdstysmsstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >6weqL (L:)
nivltqspaslavslgqratiscrasesvdsygysfmhwyqqkpgqppkvliylasnles
gvparfsgsgsrtdftltidpveaddaatyycqqnnenpltfgagtklelkradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnr