PDB entry 6wcq

View 6wcq on RCSB PDB site
Description: structure of a substrate-bound dqc ubiquitin ligase
Deposited on 2020-03-31, released 2020-08-19
The last revision was dated 2020-10-28, with a file datestamp of 2020-10-23.
Experiment type: EM
Resolution: 8.5 Å
R-factor: N/A
AEROSPACI score: -0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-phase kinase-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SKP1, EMC19, OCP2, SKP1A, TCEB1L
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: F-box/LRR-repeat protein 17
    Species: Homo sapiens [TaxId:9606]
    Gene: FBXL17, FBL17, FBX13, FBXO13
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Kelch-like ECH-associated protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: KEAP1, INRF2, KIAA0132, KLHL19
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14145
      • engineered mutation (105)
  • Chain 'D':
    Compound: Cullin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: CUL1
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wcqA (A:)
mpsiklqssdgeifevdveiakqsvtiktmledlgmddegdddpvplpnvnaailkkviq
wcthhkddppppeddenkekrtddipvwdqeflkvdqgtlfelilaanyldikglldvtc
ktvanmikgktpeeirktfnikndfteeeeaqvrkenqwceek

    Sequence, based on observed residues (ATOM records):
    >6wcqA (A:)
psiklqssdgeifevdveiakqsvtiktmledlgmddegdddpvplpnvnaailkkviqw
cthhkddpppnkekrtddipvwdqeflkvdqgtlfelilaanyldikglldvtcktvanm
ikgktpeeirktfnikndfteeeeaqvrkenqwc

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wcqB (B:)
gefmchrepppetpdinqlppsillkifsnlslderclsaslvckywrdlcldfqfwkql
dlssrqqvtdellekiasrsqniieinisdcrsmsdngvcvlafkcpgllrytayrckql
sdtsiiavashcpllqkvhvgnqdkltdeglkqlgskcrelkdihfgqcykisdegmivi
akgclklqriymqenklvtdqsvkafaehcpelqyvgfmgcsvtskgvihltklrnlssl
dlrhiteldnetvmeivkrcknlsslnlclnwiindrcveviakegqnlkelylvsckit
dyaliaigrysmtietvdvgwckeitdqgatliaqsskslrylglmrcdkvnevtveqlv
qqyphitfstvlqdckrtlerayqmgwtpnmsaass

    Sequence, based on observed residues (ATOM records):
    >6wcqB (B:)
pdinqlppsillkifsnlslderclsaslvckywrdlcldfkqldlssrqqvtdelleki
asrsqniieinisdcrsmsdngvcvlafkcpgllrytayrckqlsdtsiiavashcpllq
kvhvgnqdkltdeglkqlgskcrelkdihfgqcykisdegmiviakgclklqriymqenk
lvtdqsvkafaehcpelqyvgfmgcsvtskgvihltklrnlssldlrhiteldnetvmei
vkrcknlsslnlclnwiindrcveviakegqnlkelylvsckitdyaliaigrysmtiet
vdvgwckeitdqgatliaqsskslrylglmrcdkvnevtveqlvqqyphitfstvlqdck
rtlerayqmgwt

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wcqC (C:)
gggsggsmqpdprpsgagaccrflplqsqcpegagdavmyasteckaevtpsqhgnrtfs
ytledhtkqafgimnelrlsqqlcdvtlqvkyqdapaaqfmahkvalassspvfkamftn
glreqgmevvsiegihpkvmerliefaytasismgekcvlhvmngavmyqidsvvracsd
flvqqldpsnaigianfaeqigcvelhqrareyiymhfgevakqeeffnlshcqlvtlis
rddlnvrcesevfhacinwvkydceqrrfyvqallravrchsltpnflqmqlqkceilqs
dsrckdylvkifeeltlhkptqvmpcrapkvgrliytaggyfrqslsyleaynpsdgtwl
rladlqvprsglagcvvggllyavggrnnspdgntdssaldcynpmtnqwspcapmsvpr
nrigvgvidghiyavggshgcihhnsveryeperdewhlvapmltrrigvgvavlnrlly
avggfdgtnrlnsaecyypernewrmitamntirsgagvcvlhnciyaaggydgqdqlns
verydvetetwtfvapmkhrrsalgitvhqgriyvlggydghtfldsvecydpdtdtwse
vtrmtsgrsgvgvavtmepcrkqidqqnctc

    Sequence, based on observed residues (ATOM records):
    >6wcqC (C:)
rtfsytledhtkqafgimnelrlsqqlcdvtlqvkyqdapaaqfmahkvalassspvfka
mftnglreqgmevvsiegihpkvmerliefaytasismgekcvlhvmngavmyqidsvvr
acsdflvqql

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6wcqD (D:)
msstrsqnphglkqigldqiwddlragiqqvytrqsmaksrymelythvynyctsvhqsn
qargagvppskskkgqtpggaqfvglelykrlkeflknyltnllkdgedlmdesvlkfyt
qqwedyrfsskvlngicaylnrhwvrrecdegrkgiyeiyslalvtwrdclfrplnkqvt
navlkliekerngetintrlisgvvqsyvelglneddafakgptltvykesfesqfladt
erfytresteflqqnpvteymkkaearlleeqrrvqvylhestqdelarkceqvliekhl
eifhtefqnlldadknedlgrmynlvsriqdglgelkkllethihnqglaaiekcgeaal
ndpkmyvqtvldvhkkynalvmsafnndagfvaaldkacgrfinnnavtkmaqssskspe
llarycdsllkkss

    Sequence, based on observed residues (ATOM records):
    >6wcqD (D:)
igldqiwddlragiqqvytrqsmaksrymelythvynyctsqfvglelykrlkeflknyl
tnllkdgedlmdesvlkfytqqwedyrfsskvlngicaylnrhwvrreckgiyeiyslal
vtwrdclfrplnkqvtnavlkliekerngetintrlisgvvqsyvelglnedltvykesf
esqfladterfytresteflqqnpvteymkkaearlleeqrrvqvylhestqdelarkce
qvliekhleifhtefqnlldadknedlgrmynlvsriqdglgelkkllethihnqglaai
ekcgeaalndpkmyvqtvldvhkkynalvmsafnndagfvaaldkacgrfinnnavtk