PDB entry 6wbv

View 6wbv on RCSB PDB site
Description: structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
Deposited on 2020-03-27, released 2020-09-09
The last revision was dated 2020-11-11, with a file datestamp of 2020-11-06.
Experiment type: EM
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Solute carrier family 40 member 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC40A1, FPN1, IREG1, SLC11A3, MSTP079
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Hepcidin
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Fab45D8 Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WBV (0-219)
  • Chain 'L':
    Compound: Fab45D8 Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6WBV (0-217)
  • Heterogens: CO, AGA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wbvA (A:)
mtragdhnrqrgccgsladyltsakfllylghslstwgdrmwhfavsvflvelygnslll
tavyglvvagsvlvlgaiigdwvdknarlkvaqtslvvqnvsvilcgiilmmvflhkhel
ltmyhgwvltscyiliitianianlastataitiqrdwivvvagedrsklanmnatirri
dqltnilapmavgqimtfgspvigcgfisgwnlvsmcveyvllwkvyqktpalavkaglk
eeetelkqlnlhkdtepkplegthlmgvkdsniheleheqeptcasqmaepfrtfrdgwv
syynqpvflagmglaflymtvlgfdcittgyaytqglsgsilsilmgasaitgimgtvaf
twlrrkcglvrtglisglaqlsclilcvisvfmpgspldlsvspfedirsrfiqgesitp
tkipeitteiymsngsnsanivpetspesvpiisvsllfagviaariglwsfdltvtqll
qenviesergiingvqnsmnylldllhfimvilapnpeafgllvlisvsfvamghimyfr
faqntlgnklfacgpdakevrkenqantsvvgsglevlfqgpgaaedqvdprlidgkhhh
hhhhh

    Sequence, based on observed residues (ATOM records):
    >6wbvA (A:)
sladyltsakfllylghslstwgdrmwhfavsvflvelygnsllltavyglvvagsvlvl
gaiigdwvdknarlkvaqtslvvqnvsvilcgiilmmvflhkhelltmyhgwvltscyil
iitianianlastataitiqrdwivvvagedrsklanmnatirridqltnilapmavgqi
mtfgspvigcgfisgwnlvsmcveyvllwkvyqktpalavkagaepfrtfrdgwvsyynq
pvflagmglaflymtvlgfdcittgyaytqglsgsilsilmgasaitgimgtvaftwlrr
kcglvrtglisglaqlsclilcvisvfmpgsplpiisvsllfagviaariglwsfdltvt
qllqenviesergiingvqnsmnylldllhfimvilapnpeafgllvlisvsfvamghim
yfrfaqntl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6wbvB (B:)
dthfpicifccgcchrskcgmcckt

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >6wbvH (H:)
evqlqesgpglakpsqtlsltcsvtgssitsdywnwirkfpgnkleymgyisysgstyyn
pslksqisitrdtsknhyylqlnsvttedtatyycarqglrnwyfdvwgtgttvtvssak
ttapsvyplapvcggttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpallqsgly
tlsssvtvtsntwpsqtitcnvahpasstkvdkkieprvp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6wbvL (L:)
divltqspaslpvslgqratiscrasksvsasaysymhwyqqkpgqppkpliylasnles
gvparfsgsgsgtdftlnihpveeedaatyycqhnrelpytfgggtkleikradaaptvs
ifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysms
stltltkdeyerhnsytceathktstspivksfnrnec