PDB entry 6wbk

View 6wbk on RCSB PDB site
Description: cryo-em structure of human pannexin 1 channel with deletion of n- terminal helix and c-terminal tail
Deposited on 2020-03-26, released 2020-06-03
The last revision was dated 2020-09-09, with a file datestamp of 2020-09-04.
Experiment type: EM
Resolution: 6.01 Å
R-factor: N/A
AEROSPACI score: 0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wbkA (A:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkA (A:)
lrlelavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaa
vqqknslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeld
kvynraikaaksardfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyf
slsslsdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytl
fvpfrqktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenik
ssgqgidpmllltnl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wbkB (B:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkB (B:)
lrlelavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaa
vqqknslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeld
kvynraikaaksardfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyf
slsslsdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytl
fvpfrqktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenik
ssgqgidpmllltnl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wbkC (C:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkC (C:)
elavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaavqq
knslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeldkvy
nraikaaksardpiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssls
defvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfrq
ktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqgi
dpmllltnl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6wbkD (D:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkD (D:)
elavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaavqq
knslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeldkvy
nraikaaksardfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfsls
slsdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvp
frqktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssg
qgidpmllltnl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6wbkE (E:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkE (E:)
elavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaavqq
knslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeldkvy
nraikaaksardpiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssls
defvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfrq
ktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqgi
dpmllltn

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6wbkF (F:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkF (F:)
elavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaavqq
knslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeldkvy
nraikaaksardpiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssls
defvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfrq
ktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqgi
dpmllltnl

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6wbkG (G:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnl

    Sequence, based on observed residues (ATOM records):
    >6wbkG (G:)
lelavdkmvtciavglplllislafaqeisigtqiscfspssfswrqaafvdsycwaavq
qknslqsesgnlplwlhkffpyilllfaillylpplfwrfaaaphicsdlkfimeeldkv
ynraikaaksardfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfsl
sslsdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfv
pfrqktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikss
gqgidpmllltnl