PDB entry 6wbg

View 6wbg on RCSB PDB site
Description: cryo-em structure of human pannexin 1 channel with its c-terminal tail cleaved by caspase-7
Deposited on 2020-03-26, released 2020-06-03
The last revision was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: EM
Resolution: 2.97 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Pannexin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PANX1, MRS1, UNQ2529/PRO6028
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PTY, 3PE, DGA, CLR, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6wbgA (A:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgA (A:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6wbgB (B:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgB (B:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6wbgC (C:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgC (C:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6wbgD (D:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgD (D:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6wbgE (E:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgE (E:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6wbgF (F:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgF (F:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6wbgG (G:)
maiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisi
gtqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfaill
ylpplfwrfaaaphicsdlkfimeeldkvynraikaaksardldmrdgacsvpgvtenlg
qslwevseshfkypiveqylktkknsnnliikyiscrlltliiillaciylgyyfslssl
sdefvcsiksgilrndstvpdqfqckliavgifqllsvinlvvyvllapvvvytlfvpfr
qktdvlkvyeilptfdvlhfksegyndlslynlfleenisevksykclkvlenikssgqg
idpmllltnlgmi

    Sequence, based on observed residues (ATOM records):
    >6wbgG (G:)
aiaqlateyvfsdfllkeptepkfkglrlelavdkmvtciavglplllislafaqeisig
tqiscfspssfswrqaafvdsycwaavqqknslqsesgnlplwlhkffpyilllfailly
lpplfwrfaaaphicsdlkfimeeldkvynraikaaksardfkypiveqylktkknsnnl
iikyiscrlltliiillaciylgyyfslsslsdefvcsiksgilrndstvpdqfqcklia
vgifqllsvinlvvyvllapvvvytlfvpfrqktdvlkvyeilptfdvlhfksegyndls
lynlfleenisevksykclkvlenikssgqgidpmllltnlgmi