PDB entry 6wak

View 6wak on RCSB PDB site
Description: A crystal structure of EGFR(T790M/V948R) in complex with LN3754
Class: transferase
Keywords: Cancer, TRANSFERASE, inhibitor
Deposited on 2020-03-25, released 2021-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6waka_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6wakb_
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6wakc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (95)
      • engineered mutation (253)
    Domains in SCOPe 2.08: d6wakd_
  • Heterogens: TQA, ANP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6wakA (A:)
    sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
    ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
    lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
    kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
    qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
    snfyralmdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6wakA (A:)
    allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
    eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
    akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllggkvpikwmalesilhriy
    thqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcw
    midadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeevda
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6wakB (B:)
    sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
    ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
    lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
    kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
    qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
    snfyralmdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6wakB (B:)
    qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeil
    deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
    iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhkvpikwmale
    silhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvy
    mimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmde
    edmddvvdadeylipq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6wakC (C:)
    sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
    ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
    lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
    kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
    qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
    snfyralmdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6wakC (C:)
    qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeil
    deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
    iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakvpikwmalesilhriythqs
    dvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmida
    dsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6wakD (D:)
    sgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspk
    ankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyl
    lnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaegg
    kvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlp
    qppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptd
    snfyralmdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6wakD (D:)
    qallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreakankeildea
    yvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiak
    gmnyledrrlvhrdlaarnvlvktpqhvkitdfglaklvpikwmalesilhriythqsdv
    wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidads
    rpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad