PDB entry 6w8d

View 6w8d on RCSB PDB site
Description: structure of dnmt3a (r882h) in complex with cgt dna
Deposited on 2020-03-20, released 2020-04-15
The last revision was dated 2020-05-20, with a file datestamp of 2020-05-15.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA (cytosine-5)-methyltransferase 3A
    Species: Homo sapiens [TaxId:9606]
    Gene: DNMT3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y6K1 (Start-284)
      • engineered mutation (254)
  • Chain 'B':
    Compound: DNA (cytosine-5)-methyltransferase 3-like
    Species: Homo sapiens [TaxId:9606]
    Gene: DNMT3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA (cytosine-5)-methyltransferase 3-like
    Species: Homo sapiens [TaxId:9606]
    Gene: DNMT3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA (cytosine-5)-methyltransferase 3A
    Species: Homo sapiens [TaxId:9606]
    Gene: DNMT3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y6K1 (0-284)
      • engineered mutation (254)
  • Chain 'E':
    Compound: cgt DNA (25-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'F':
    Compound: cgt DNA (25-mer)
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: SAH, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6w8dA (A:)
    aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdv
    rsvtqkhiqewgpfdlviggspcndlsivnparkglyegtgrlffefyrllhdarpkegd
    drpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplas
    tvndklelqeclehgriakfskvrtittrsnsikqgkdqhfpvfmnekedilwctemerv
    fgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
    

    Sequence, based on observed residues (ATOM records):
    >6w8dA (A:)
    ekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvr
    svtqkhiqewgpfdlviggspcndlsivnparkglyegtgrlffefyrllhdarpkegdd
    rpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplast
    vndklelqeclehgriakfskvrtittrsnsikqgkdqhfpvfmnekedilwctemervf
    gfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6w8dB (B:)
    mfetvpvwrrqpvrvlslfedikkeltslgflesgsdpgqlkhvvdvtdtvrkdveewgp
    fdlvygatpplghtcdrppswylfqfhrllqyarpkpgsprpffwmfvdnlvlnkedldv
    asrflemepvtipdvhggslqnavrvwsnipairsrhwalvseeelsllaqnkqssklaa
    kwptklvkncflplreyfkyfsteltssl
    

    Sequence, based on observed residues (ATOM records):
    >6w8dB (B:)
    fetvpvwrrqpvrvlslfedikkeltslgflesgsqlkhvvdvtdtvrkdveewgpfdlv
    ygatpplghtcdrppswylfqfhrllqyarpkpgsprpffwmfvdnlvlnkedldvasrf
    lemepvtipdvlqnavrvwsnipairsrhwalvseeelsllaqnkqsstklvkncflplr
    eyfkyfs
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6w8dC (C:)
    mfetvpvwrrqpvrvlslfedikkeltslgflesgsdpgqlkhvvdvtdtvrkdveewgp
    fdlvygatpplghtcdrppswylfqfhrllqyarpkpgsprpffwmfvdnlvlnkedldv
    asrflemepvtipdvhggslqnavrvwsnipairsrhwalvseeelsllaqnkqssklaa
    kwptklvkncflplreyfkyfsteltssl
    

    Sequence, based on observed residues (ATOM records):
    >6w8dC (C:)
    rqpvrvlslfedikkeltslgfpgqlkhvvdvtdtvrkdveewgpfdlvygatpplghdr
    ppswylfqfhrllqyarpkpgsprpffwmfvdnlvlnkedldvasrflemepvtipdvhl
    qnavrvwsnipairsrhwalvseeelsllaqnkqsskwptklvkncflplreyfkyf
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6w8dD (D:)
    aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdv
    rsvtqkhiqewgpfdlviggspcndlsivnparkglyegtgrlffefyrllhdarpkegd
    drpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplas
    tvndklelqeclehgriakfskvrtittrsnsikqgkdqhfpvfmnekedilwctemerv
    fgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
    

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.