PDB entry 6w6g

View 6w6g on RCSB PDB site
Description: The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation I in the presence of DnaK chaperone and a model substrate
Class: chaperone
Keywords: ClpB/DnaK, protein aggregates, unfold, Refold protein, CHAPERONE
Deposited on 2020-03-16, released 2021-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-26, with a file datestamp of 2021-05-21.
Experiment type: EM
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6ga1, d6w6ga2
  • Chain 'B':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6gb1, d6w6gb2
  • Chain 'C':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6gc1, d6w6gc2
  • Chain 'D':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6gd1
  • Chain 'E':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6ge1
  • Chain 'F':
    Compound: Chaperone protein ClpB
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: clpB, MT0397
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w6gf1
  • Chain 'N':
    Compound: substrate
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W6G (0-End)
  • Heterogens: ADP, AGS

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w6gA (A:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gA (A:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmvagskyrgefeerlkavlddiknsagqiitfid
elhtivgagaagnmikpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsve
dtigilrglkdryevhhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrme
idsrpveideverlvrrleieemalskeedeasaerlaklrseladqkeklaelttrwqn
eknakeevgpddiadvvsawtgipagrllegetakllrmedelgkrvigqkaavtavsda
vrrsragvsdpnrptgafmflgptgvgktelakaladflfdderamvridmseygekhtv
arligappgyvgyeaggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdgh
grtvdfrntililtsnlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvriv
diqlaqlgkrlaqrrlqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmlla
gqvhdgdtvpvnvspdadsl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w6gB (B:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gB (B:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmvagskyrgefeerlkavlddiknsagqiitfid
elhtivgagadagnmikpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsv
edtigilrglkdryevhhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrm
eidsrpveideverlvrrleieemalskeedeasaerlaklrseladqkeklaelttrwq
neknakeevgpddiadvvsawtgipagrllegetakllrmedelgkrvigqkaavtavsd
avrrsragvsdpnrptgafmflgptgvgktelakaladflfdderamvridmseygekht
varligappgyvgyeaggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdg
hgrtvdfrntililtsnlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvri
vdiqlaqlgkrlaqrrlqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmll
agqvhdgdtvpvnvspdadsl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6w6gC (C:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gC (C:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmvagskyrgefeerlkavlddiknsagqiitfid
elhtivgagatamdagnmikpmlargelrlvgattldeyrkhiekdaalerrfqqvyvge
psvedtigilrglkdryevhhgvritdsalvaaatlsdryitarflpdkaidlvdeaasr
lrmeidsrpveideverlvrrleieemalskeedeasaerlaklrseladqkeklaeltt
rwqneknakeevgpddiadvvsawtgipagrllegetakllrmedelgkrvigqkaavta
vsdavrrsragvsdpnrptgafmflgptgvgktelakaladflfdderamvridmseyge
khtvarligappgyvgyeaggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrl
tdghgrtvdfrntililtsnlgsggsaeqvlaavratfkpefinrlddvlifeglnpeel
vrivdiqlaqlgkrlaqrrlqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlak
mllagqvhdgdtvpvnvspdadsl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6w6gD (D:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gD (D:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmvagskyrgefeerlkavlddiknsagqiitfid
elhtivgagadagnmikpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsv
edtigilrglkdryevhhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrm
eidsrpkeevgpddiadvvsawtgipagrllegetakllrmedelgkrvigqkaavtavs
davrrsragvsdpnrptgafmflgptgvgktelakaladflfdderamvridmseygekh
tvarligappgyvgyeaggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltd
ghgrtvdfrntililtsnlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvr
ivdiqlaqlgkrlaqrrlqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakml
lagqvhdgdtvpvnvspdadsl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6w6gE (E:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gE (E:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmvrgefeerlkavlddiknsagqiitfidelhti
vgnmikpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglk
dryevhhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidkeevgpdd
iadvvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpn
rptgafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvg
yeaggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntili
ltsnlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrla
qrrlqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvn
vspdadsl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6w6gF (F:)
mdsfnpttktqaaltaalqaastagnpeirpahllmalltqndgiaaplleavgvepatv
raetqrlldrlpqatgastqpqlsreslaaittaqqlatelddeyvstehvmvglatgds
dvaklltghgaspqalreafvkvrgsarvtspepeatyqalqkystdltararegkldpv
igrdneirrvvqvlsrrtknnpvligepgvgktaiveglaqrivagdvpeslrdktival
dlgsmvagskyrgefeerlkavlddiknsagqiitfidelhtivgagatgegamdagnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidsrpveideverlv
rrleieemalskeedeasaerlaklrseladqkeklaelttrwqneknaieivrdlkeql
ealrgeseraerdgdlakaaelrygripevekkldaalpqaqareqvmlkeevgpddiad
vvsawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrpt
gafmflgptgvgktelakaladflfdderamvridmseygekhtvarligappgyvgyea
ggqlteavrrrpytvvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililts
nlgsggsaeqvlaavratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrr
lqlqvslpakrwlaqrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvsp
dadslilg

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6gF (F:)
qalqkystdltararegkldpvigrdneirrvvqvlsrrtknnpvligepgvgktaiveg
laqrivagdvpeslrdktivaldlgsmfeerlkavlddiknsagqiitfidelhtivnmi
kpmlargelrlvgattldeyrkhiekdaalerrfqqvyvgepsvedtigilrglkdryev
hhgvritdsalvaaatlsdryitarflpdkaidlvdeaasrlrmeidkeevgpddiadvv
sawtgipagrllegetakllrmedelgkrvigqkaavtavsdavrrsragvsdpnrptga
fmflgptgvgktelakaladflfdderamvridmseygekhtvarligqlteavrrrpyt
vvlfdeiekahpdvfdvllqvldegrltdghgrtvdfrntililtsnlgsggsaeqvlaa
vratfkpefinrlddvlifeglnpeelvrivdiqlaqlgkrlaqrrlqlqvslpakrwla
qrgfdpvygarplrrlvqqaigdqlakmllagqvhdgdtvpvnvspdadsl

  • Chain 'N':
    No sequence available.