PDB entry 6w6d

View 6w6d on RCSB PDB site
Description: Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor
Class: TRANSFERASE/TRANSFERASE Inhibitor
Keywords: PRMT6 and SGC6870 inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex
Deposited on 2020-03-16, released 2020-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein arginine N-methyltransferase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PRMT6, HRMT1L6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96LA8 (Start-375)
      • conflict (194)
    Domains in SCOPe 2.08: d6w6da_
  • Heterogens: T9A, SAH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w6dA (A:)
gmsqpkkrklesggggeggegteeedgaereaalerprrtkrerdqlyyecysdvsvhee
miadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqagarrvyaveasaiwqq
arevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhesmlssvlhartkwlk
egglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegfatrclmghseivvq
glsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapmhgfaiwfqvtfpgg
esekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsrdnprrlrvllry
kvgdqeektkdfamed

    Sequence, based on observed residues (ATOM records): (download) 
    >6w6dA (A:)
lyyecysdvsvheemiadrvrtdayrlgilrnwaalrgktvldvgagtgilsifcaqaga
rrvyaveasaiwqqarevvrfngledrvhvlpgpvetvelpeqvdaivsewmgygllhes
mlssvlhartkwlkegglllpasaelfivpisdqmlewrlgfwsqvkqhygvdmsclegf
atrclmghseivvqglsgedvlarpqrfaqlelsragleqeleagvggrfrcscygsapm
hgfaiwfqvtfpggekplvlstspfhpathwkqallylnepvqveqdtdvsgeitllpsr
dnprrlrvllrykvgdqeektkdfamed