PDB entry 6w5t

View 6w5t on RCSB PDB site
Description: npc1 structure in gdn micelles at ph 5.5, conformation a
Deposited on 2020-03-13, released 2020-06-17
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-17.
Experiment type: EM
Resolution: 3.7 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NPC intracellular cholesterol transporter 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NPC1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CLR, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6w5tA (A:)
mtarglalgllllllcpaqvfsqscvwygecgiaygdkrynceysgppkplpkdgydlvq
elcpgfffgnvslccdvrqlqtlkdnlqlplqflsrcpscfynllnlfceltcsprqsqf
lnvtatedyvdpvtnqtktnvkelqyyvgqsfanamynacrdveapssndkalgllcgkd
adacnatnwieymfnkdngqapftitpvfsdfpvhgmepmnnatkgcdesvdevtapcsc
qdcsivcgpkpqpppppapwtilgldamyvimwitymafllvffgaffavwcyrkryfvs
eytpidsniafsvnasdkgeasccdpvsaafegclrrlftrwgsfcvrnpgcviffslvf
itacssglvfvrvttnpvdlwsapssqarlekeyfdqhfgpffrteqliirapltdkhiy
qpypsgadvpfgppldiqilhqvldlqiaienitasydnetvtlqdiclaplspyntnct
ilsvlnyfqnshsvldhkkgddffvyadyhthflycvrapaslndtsllhdpclgtfggp
vfpwlvlggyddqnynnatalvitfpvnnyyndteklqraqawekefinfvknyknpnlt
isftaersiedelnresdsdvftvvisyaimflyislalghmkscrrllvdskvslgiag
ilivlssvacslgvfsyiglpltlivievipflvlavgvdnifilvqayqrderlqgetl
dqqlgrvlgevapsmflssfsetvafflgalsvmpavhtfslfaglavfidfllqitcfv
sllgldikrqeknrldifccvrgaedgtsvqasesclfrffknsysplllkdwmrpivia
ifvgvlsfsiavlnkvdigldqslsmpddsymvdyfksisqylhagppvyfvleeghdyt
sskgqnmvcggmgcnndslvqqifnaaqldnytrigfapsswiddyfdwvkpqssccrvd
nitdqfcnasvvdpacvrcrpltpegkqrpqggdfmrflpmflsdnpnpkcgkgghaays
savnillghgtrvgatyfmtyhtvlqtsadfidalkkarliasnvtetmgingsayrvfp
ysvfyvfyeqyltiiddtifnlgvslgaiflvtmvllgcelwsavimcatiamvlvnmfg
vmwlwgislnavslvnlvmscgisvefcshitraftvsmkgsrveraeealahmgssvfs
gitltkfggivvlafaksqifqifyfrmylamvllgathgliflpvllsyigpsvnkaks
cateerykgtererllnflegsdevdagshhhhhhhhhhgsvedykddddk

    Sequence, based on observed residues (ATOM records):
    >6w5tA (A:)
qscvwygecgiaygdkrynceysgppkplpkdgydlvqelcpgfffgnvslccdvrqlqt
lkdnlqlplqflsrcpscfynllnlfceltcsprqsqflnvtatedyvdpvtnqtktnvk
elqyyvgqsfanamynacrdveapssndkalgllcgkdadacnatnwieymfnkdngqap
ftitpvfsdfpvhgmepmnnatkgcdesvdevtapcscqdcsivcgpkpqpppppapwti
lgldamyvimwitymafllvffgaffavwcyrkpvsaafegclrrlftrwgsfcvrnpgc
viffslvfitacssglvfvrvttnpvdlwsapssqarlekeyfdqhfgpffrteqliira
pltdkhiyqpypsgadvpfgppldiqilhqvldlqiaienitasydnetvtlqdiclapl
spyntnctilsvlnyfqnshsvldhkkgddffvyadyhthflycvrapaslndtsllhdp
clgtfggpvfpwlvlggyddqnynnatalvitfpvnnyyndteklqraqawekefinfvk
nyknpnltisftaersiedelnresdsdvftvvisyaimflyislalghvdskvslgiag
ilivlssvacslgvfsyiglpltlivievipflvlavgvdnifilvqayqrderlqgetl
dqqlgrvlgevapsmflssfsetvafflgalsvmpavhtfslfaglavfidfllqitcfv
sllgldikrqeknrsclfrffknsysplllkdwmrpiviaifvgvlsfsiavlnkvdigl
dqslsmpddsymvdyfksisqylhagppvyfvleeghdytsskgqnmvcggmgcnndslv
qqifnaaqldnytrigfapsswiddyfdwvkpqssccrvdnitdqfcnasvvdpacvrcr
pltpegkqrpqggdfmrflpmflsdnpnpkcgkgghaayssavnillghgtrvgatyfmt
yhtvlqtsadfidalkkarliasnvtetmgingsayrvfpysvfyvfyeqyltiiddtif
nlgvslgaiflvtmvllgcelwsavimcatiamvlvnmfgvmwlwgislnavslvnlvms
cgisvefcshitraftvsmkgsrveraeealahmgssvfsgitltkfggivvlafaksqi
fqifyfrmylamvllgathgliflpvllsyigpsv