PDB entry 6w5k

View 6w5k on RCSB PDB site
Description: 1.95 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5g
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: PROTEASE, Norovirus 3CL protease, Inhibitors, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2020-03-13, released 2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (5)
    Domains in SCOPe 2.08: d6w5ka1, d6w5ka2
  • Chain 'B':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (4-5)
    Domains in SCOPe 2.08: d6w5kb1, d6w5kb2
  • Chain 'C':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (4-5)
    Domains in SCOPe 2.08: d6w5kc1, d6w5kc2
  • Chain 'D':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (5)
    Domains in SCOPe 2.08: d6w5kd1, d6w5kd2
  • Heterogens: TKV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w5kA (A:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5kA (A:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptvkeffgeplsiaihqageftqfrfs
kkmrpdltgmvleegcegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgmll
lgtipgdcgapyvhkrgwvvcgvhaaatksntvvcavq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w5kB (B:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5kB (B:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkffgeplsiaihqageftqfrf
skkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgm
lllgtipgdcgapyvhkrgdwvvcgvhaaatksgntvvcavqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6w5kC (C:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5kC (C:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgepliaihqageftqfrf
skkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgm
lllgtipgdcgapyvhkrgndwvvcgvhaaatntvvcavq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6w5kD (D:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5kD (D:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrwvvcgvhaaatksntvvcavqa