PDB entry 6w4o

View 6w4o on RCSB PDB site
Description: camkii alpha-30 cryo-em reconstruction
Deposited on 2020-03-11, released 2020-07-15
The last revision was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: EM
Resolution: 4.8 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CAMK2A, CAMKA, KIAA0968
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UQM7 (1-End)
      • engineered mutation (36)
      • conflict (129)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6w4oA (A:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oA (A:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
rnskpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqi
vhfhrsga

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6w4oB (B:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oB (B:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
kpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhf
hrsgap

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6w4oC (C:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oC (C:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
skpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivh
fhrsga

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6w4oD (D:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oD (D:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
gap

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6w4oE (E:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oE (E:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
gap

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6w4oF (F:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oF (F:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenkpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
ga

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6w4oG (G:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oG (G:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
rnskpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqi
vhfhrsga

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6w4oI (I:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oI (I:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
kpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhf
hrsgap

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6w4oJ (J:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oJ (J:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlws
skpvhttilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivh
fhrsga

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6w4oK (K:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oK (K:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
gap

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6w4oL (L:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oL (L:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenlpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
gap

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6w4oM (M:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oM (M:)
vrkqeiikvteqlieaisngdfesytkmcdpgmtafepealgnlvegldfhrfyfenkpv
httilnphihlmgdesaciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrs
ga

  • Chain 'O':
    Sequence, based on SEQRES records:
    >6w4oO (O:)
strfteeyqlfeelgkgafsvvrrcvkvlagqeyaamiintkklsardhqklerearicr
llkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlh
chqmgvvhrnlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevl
rkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeak
dlinkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkgailt
tmlatrnfsggksggnkksdgvkessestnttiededtkvrkqeiikvteqlieaisngd
fesytkmcdpgmtafepealgnlvegldfhrfyfenlwsrnskpvhttilnphihlmgde
saciayiritqyldaggiprtaqseetrvwhrrdgkwqivhfhrsgapsvlph

    Sequence, based on observed residues (ATOM records):
    >6w4oO (O:)
trfteeyqlfeelgkgsvvrrcvkvlagqeyaamiintkklsardhqklerearicrllk
hpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlhchq
mgvvhrnlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevlrkd
pygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdli
nkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklkg