PDB entry 6w4f

View 6w4f on RCSB PDB site
Description: NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc
Class: oncoprotein
Keywords: GTPase, nanodisc, ONCOPROTEIN
Deposited on 2020-03-10, released 2020-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-08, with a file datestamp of 2020-07-03.
Experiment type: NMR
Resolution: N/A
R-factor: N/A
AEROSPACI score: 0 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apolipoprotein a-I
    Species: Homo sapiens [TaxId:9606]
    Gene: APOA1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02647
      • expression tag (198-199)
    Domains in SCOPe 2.08: d6w4fa1, d6w4fa2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (0-End)
      • conflict (10)
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (0-End)
      • conflict (10)
  • Chain 'D':
    Compound: apolipoprotein a-I
    Species: Homo sapiens [TaxId:9606]
    Gene: APOA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w4fd_
  • Heterogens: PCW, 17F, GDP, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w4fA (A:)
gplklldnwdsvtstfsklreqlgpvtqefwdnleketeglrqemskdleevkakvqpyl
ddfqkkwqeemelyrqkveplraelqegarqklhelqeklsplgeemrdrarahvdalrt
hlapysdelrqrlaarlealkenggarlaeyhakatehlstlsekakpaledlrqgllpv
lesfkvsflsaleeytkkln

    Sequence, based on observed residues (ATOM records): (download) 
    >6w4fA (A:)
lklldnwdsvtstfsklreqlgpvtqefwdnleketeglrqemskdleevkakvqpyldd
fqkkwqeemelyrqkveplraelqegarqklhelqeklsplgeemrdrarahvdalrthl
apysdelrqrlaarlealkenggarlaeyhakatehlstlsekakpaledlrqgllpvle
sfkvsflsaleeytkkln

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6w4fD (D:)
gplklldnwdsvtstfsklreqlgpvtqefwdnleketeglrqemskdleevkakvqpyl
ddfqkkwqeemelyrqkveplraelqegarqklhelqeklsplgeemrdrarahvdalrt
hlapysdelrqrlaarlealkenggarlaeyhakatehlstlsekakpaledlrqgllpv
lesfkvsflsaleeytkkln

    Sequence, based on observed residues (ATOM records): (download) 
    >6w4fD (D:)
lklldnwdsvtstfsklreqlgpvtqefwdnleketeglrqemskdleevkakvqpyldd
fqkkwqeemelyrqkveplraelqegarqklhelqeklsplgeemrdrarahvdalrthl
apysdelrqrlaarlealkenggarlaeyhakatehlstlsekakpaledlrqgllpvle
sfkvsflsaleeytkkln