PDB entry 6w2b

View 6w2b on RCSB PDB site
Description: anomalous bromine signal reveals the position of br-paroxetine complexed with the serotonin transporter at the central site
Deposited on 2020-03-05, released 2020-03-25
The last revision was dated 2020-09-23, with a file datestamp of 2020-09-18.
Experiment type: XRAY
Resolution: 4.7 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium-dependent serotonin transporter
    Species: Homo sapiens [TaxId:9606]
    Gene: SLC6A4, HTT, SERT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31645 (2-End)
      • expression tag (0-1)
      • conflict (36)
      • conflict (217)
      • conflict (480)
      • conflict (506)
  • Chain 'B':
    Compound: 8B6 heavy chain antibody fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W2B (0-End)
  • Chain 'C':
    Compound: 8B6 light chain antibody fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W2B (0-213)
  • Heterogens: RFS, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6w2bA (A:)
gsqgeretwgkkvdfllsvigyavdlgnvwrfpyicaqngggafllpytimaifggiplf
ymelalgqyhrngcisiwrkicpifkgigyaiciiafyiasyyntimawalyylissftd
qlpwtscknswntgnctnyfsednitwtlhstspaeefytrhvlqihrskglqdlggisw
qlalcimliftviyfsiwkgvktsgkvvwvtatfpyialsvllvrgatlpgawrgvlfyl
kpnwqklletgvwidaaaqiffslgpgfgvllafasynkfnnncyqdalvtsvvncmtsf
vsgfviftvlgymaemrnedvsevakdagpsllfityaeaianmpastffaiifflmlit
lgldstfaglegvitavldefphvwakrrerfvlavvitcffgslvtltfggayvvklle
eyatgpavltvalieavavswfygitqfcrdvkemlgfspgwfwricwvaisplfllfii
asflmsppqlrlfqynypywsiilgyaigtssficiptyiayrliitpgtfkeriiksit
petptlvpr

    Sequence, based on observed residues (ATOM records):
    >6w2bA (A:)
gsqgeretwgkkvdfllsvigyavdlgnvwrfpyicaqngggafllpytimaifggiplf
ymelalgqyhrngcisiwrkicpifkgigyaiciiafyiasyyntimawalyylissftd
qlpwtscknswntgnctnyfsednitwtlhstspaeefytrhvlqihrskglqdlggisw
qlalcimliftviyfsiwkgvktsgkvvwvtatfpyialsvllvrgatlpgawrgvlfyl
kpnwqklletgvwidaaaqiffslgpgfgvllafasynkfnnncyqdalvtsvvncmtsf
vsgfviftvlgymaemrnedvsevakdagpsllfityaeaianmpastffaiifflmlit
lgldstfaglegvitavldefphvwakrrerfvlavvitcffgslvtltfggayvvklle
eyatgpavltvalieavavswfygitqfcrdvkemlgfspgwfwricwvaisplfllfii
asflmsppqlrlfqynypywsiilgyaigtssficiptyiayrliitpgtfkeriiksit
petp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6w2bB (B:)
evqlqqsgpelvkpgasvkisckasgytftdyymnwvkqshgkslewigninpnnggtsy
nqkfkgkatltvdkssttaymelrsltsedsavyyctrspvrpyyfdywgqgttltvssa
kttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtwnsgslsssvhtfpallqsgl
ytmsssvtvpsstwpsqtvtcsvahpassttvdkkleprgshhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6w2bB (B:)
evqlqqsgpelvkpgasvkisckasgytftdyymnwvkqshgkslewigninpnnggtsy
nqkfkgkatltvdkssttaymelrsltsedsavyyctrspvrpyyfdywgqgttltvssa
kttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtwnsgslsssvhtfpallqsgl
ytmsssvtvpsstwpsqtvtcsvahpassttvdkklep

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6w2bC (C:)
divmtqshkfmstsvgdrvsitckasqdvstavawyqqkpgqspklliysasyrytgvpd
rftgsgsgtdftftissvqaedlavyycqqhysiprtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec