PDB entry 6w10

View 6w10 on RCSB PDB site
Description: Structure of mouse TREX1 with E198K disease-associated mutation
Class: hydrolase
Keywords: nuclease, DNase, innate immunity, autoimmunity, HYDROLASE
Deposited on 2020-03-03, released 2021-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Three-prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91XB0
      • engineered mutation (198)
    Domains in SCOPe 2.08: d6w10a_
  • Chain 'B':
    Compound: Three-prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91XB0 (1-End)
      • expression tag (0)
      • engineered mutation (198)
    Domains in SCOPe 2.08: d6w10b1, d6w10b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w10A (A:)
smgsqtlphghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvpr
pprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpc
clvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksysl
gsiytrlywqaptdshtakgdvltllsicqwkpqallqwvdeharpfstvkpmygtpatt
gtt

    Sequence, based on observed residues (ATOM records): (download) 
    >6w10A (A:)
tlphghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprpprvv
dklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcclvah
ngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqassksyslgsiytrlywqap
tdshtakgdvltllsicqwkpqallqwvdeharpfstvkpmyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w10B (B:)
smgsqtlphghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvpr
pprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpc
clvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksysl
gsiytrlywqaptdshtakgdvltllsicqwkpqallqwvdeharpfstvkpmygtpatt
gtt

    Sequence, based on observed residues (ATOM records): (download) 
    >6w10B (B:)
smgsqtlphghmqtlifldleatglpssrpevtelcllavhrralepppvprpprvvdkl
slciapgkacslskaelevqgrqrfddnlaillraflqrqpqpcclvahngdrydfpllq
telarlstpspldgtfcvdsiaalkaleqksyslgsiytrlywqaptdshtakgdvltll
sicqwkpqallqwvdeharpfstvkpmyg